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Question 1 LSpts Professor Dorothy Hodgkin was awarded the Nobel Prize in 1964 for deciphering the structure of insulin using the technique of X-ray crystallography. True False Question 2 Ltipts Molecular dynamics simulations show that the structure of proteins is encoded in their structure. is static, like a sculpture. is dynamic; proteins constantly shake and bend. Question 3 b
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Related Questions
Question 20
Signal sequences are often found at the C-terminus of the polypeptide chain.
True
False
Question 21
Attachment of an isoprenid group to a protein to form a lipid-linked protein
Palmitoylation
Acetylation
Prenylation
Lipidation
Question 22
Each GroEL subunit has an ATP-binding pocket that catalyzes hydrolysis of its bound ATP
True
False
Question 23
Calnexin and calreticulin recognize lipid molecules covalently attached to proteins to assist proper folding and translocation
O True
O False
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Question 4
Which of the following represents an example of a proteoglycan?
attachment of several molecules of heparin to the peptide antithrombin II
attachment of a Gal-B(1,3)-GalNAc disaccharide to the fish antifreeze protein
attachment of a small oligosaccharide to an immunoglobulin
O attachment of a small antigenic determinant to a membrane bound protein of a cell
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Question 22
Each GroEL subunit has an ATP-binding pocket that catalyzes hydrolysis of its bound ATP
True
False
Question 23
Calnexin and calreticulin recognize lipid molecules covalently attached to proteins to assist proper folding and translocation
True
False
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Question 8
Which statement about N-linked glycosylation is correct?
O N-linked oligosaccharides are attached to proteins one sugar at the time in the endoplasmicreticulum.
O N-linked sugars are attached to proteins as a 14 residue oligosaccharide during translation in the endoplasmic reticulum.
O N-linked sugars are attached to proteins as a 14 residue oligosaccharide during translation inthe cytoplasm.
O N-linked sugars are attached to proteins as a 14 residue oligosaccharide after translation inthe Golgi apparatus.
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PDB code
7BSJ
Questions
Q1 - What is the name of the protein
Q2 - What does the protein do?
Q3 - What are the structural features of the protein?
Q4 - What are two features of your protein’s structure that make it different OR similar to haemoglobin?
Q5 - Based on the structural properties of your protein, how resistant (or sensitive) would your protein be to heat denaturation and why?
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Question 14
The folding of an unfolded protein proceeds from low entropy disordered state to a single high entropy, low energy native conformation
O True
O False
Question 15
The GroES subunit has 14 identical 549-residue subunits arranged in two stacked rings with 7 subunits eac
True
False
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QUESTION 1
A macromolecule binding to its ligand at 1x 10Mis considered weak binding.
True
O False
QUESTION 2
For protein structure determined using X-ray difraction with the 1.1-Angatrom resolution, the electron density of the hydrogeon atoms becomes
clearly visible
True
False
QUESTION 3
In Creutzfeldt-Jakob disease, the native prion proteins that are alpha rich in the structure are mistolded to beta rich structures that nucleate to form
an amyloid iber. These prion proteins are extremely stable at physiological temperatures
True
False
QUESTION 4
is a high-pressure cell homogenizer used for generating cell lysate.
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Question 1
Signal sequences direct their delivery to different locations in the cell or outside the cell
True
False
Question 2
Which protein targeting pathway refers to the movement of polypeptides through the membrane as it is being synthesized?
Proteolysis
O removal of phosphoryl group
O acetylation
O None of the given
Question 3
Molecular chaperones stabilize unfolded proteins and bind to protein in the native conformation
O True
False
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Biological waxes are all
Question 6 options:
Cholesterol is a sterol that is commonly found in mammals.
Sterols are precursors of steroid hormones.
Sterols are more common in plasma membranes than in intracellular membranes (mitochondria, lysosomes, etc.).
None of the answers are correct
Sterols are commonly found in bacterial membranes.
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QUESTION 4
What percent are the following two 20 amino acid peptides similar?
MTEKRVQDKAKLIVDEQACT
MTDVRIQERTKLKVFEQLCI
O 25%
O 25%
O 75%
90%
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Question 9
Choose the CORRECT statement.
O A polypeptide chain may have abrupt changes in direction and restriction in geometry because of the presence of glycine
O A polypeptide chain may have abrupt changes in direction and restriction in geometry because of the presence of valine
O A polypeptide chain may have abrupt changes in direction and restriction in geometry because of the presence of arginine
O A polypeptide chain may have abrupt changes in direction and restriction in geometry because of the presence of proline
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Question 9
What structural features are true regarding the transmembrane and cytoplasmic domains? Choose
all that apply
a stretch of about 20 hydrophobic residues with non-conserved sequences is anchoring the transmembrane
domain
no non-catalytic sequences are found
non-catalytic sequences are on both sides of the catalytic part of the protein
no sequence similarity is found for the intracellular domain
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Question 28 : In a SDS-PAGE analysis (Indicate the right answer) :
A- The proteins are denatured and positively charged by the addition of SDS.
B- Large proteins run faster than small proteins.
C- If the pHi of a protein corresponds to the pH of the running buffer the protein becomes
positively charged (+) and cannot migrate anymore into the gel.
D- For reducing disulfide bridges one needs to add a reducing agent such as 2-mercaptoethanol
or DTT.
E- All is wrong.
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izzing/user/attempt/quiz_start_frame_auto.d21?ou=D3269550&isprv3&drc%3D1&qi=1995726&cfql=0&dnb3D0&fror
12
Time Left:0:04:09
Angelina Tran: Attempt 1
O anabolism
Question 50 (2 points)
Listen
Which of the following is NOT part of the endomembrane system?
O chloroplast
plasma membrane
vesicles
endoplasmic reticulum
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Which statement about sickle cell anemia is FALSE?
Question 28 options:
cells containing the mutated hemoglobin change in shape and can block capillaries
the amino acid mutation involved is from a charged residue to a polar, uncharged residue
it involves a hydrophobic patch on the surface of hemoglobin that causes hemoglobin to stick to itself
the sickle cell mutation provides some resistance to malaria
it can be caused by a single amino acid mutation in one chain of hemoglobin
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Time left 2:56:36
Question
100
Glycosidic bond links two amino acids together in a polypeptide chain.
Select one:
Not yet
answered
OTrue
Marked out of
O False
1.00
P Flag
question
Question
101
All of the following correctly describe the sodium-potassium pump EXCEPT:
Oa.
A total of five binding sites are present in the sodium-potassium pump
Not yet
answered
O b. Potassium ions are pumped into the cell, where they are present in lower concentration than the
Marked out of
extracellular fluid
1.00
O c. Molecules are pumped from low concentration to high concentration
P Flag
question
O d. Energy is required for the process to take place
O e. The transport proteins will undergo some conformational changes
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Question
True/False Question:
Cholesterol is the main storage form of lipids in plants and anmals.
True
False
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Question:
A sample of 5 mL of blood is tested for the enzyme creatine kinase (CK). The blood test reveals that the sample contains a total amount of 1.050 IU of CK. The normal range for CK in a blood test is 25-200 IU per liter. The patient from whom this blood was drawn then has creatine kinase levels that are
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offset=next&assignment ProblemID=218423920 Which of the following statements is FALSE regarding proteins? The three-dimensional shape of a protein is critical for the functioning of that protein. O There is a link between improperly folded proteins and disease in both mad cow disease and Alzheimer's disease. Alzheimer's disease causes proteins in the brain to become improperly folded. O High heat and a change in pH can denature a protein. Submit Part C Request Answer Why does the story in the video start in Colombia? <
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Question 7
Which of the following translocases serves as the central entry gate for cytosolic precursor proteins imported into the mitochondria?
O TIM 23
SAM complex
O TIM 22
OTOM complex
Question 8
Protein disulfide isomerase catalyzes the disulfide interchange reactions in polypeptides during protein folding in vivo
True
False
Question 9
Protein lipidation occurs in the following cellular sites, EXCEPT
Golgi
O ER
Cytoplasm
None of the given
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Question 4. Imagine the main chain of a protein bends
back on itself so that two amino acid residues R1 and R2
come close to each other.
In the table below are four possibilities for what R1 and
R2 might be. In each case, decide whether a specific
interaction could form between the residues. If a specific
interaction could form, give the name of the interaction.
R₁
cysteine
tyrosine
threonine
arginine
R₂
cysteine
phenylalanine
glutamine
aspartate
specific
interaction?
OO
yes
O yes
O no
no
OO
O yes
no
yes
no
name of specific
interaction
0
П
0
0
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Please help me answer questions Part IV- 1, 3, 4
Thank you,
Heres a link to the PDF
https://www.cusd80.com/cms/lib/AZ01001175/Centricity/Domain/8922/eofad.pdf
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I need help with these tables.
Q8 is a comparison between simple and complex proteins. I guessed a few of them
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Question 3 of 3 >
r:
te
e
Select the true statements about protein secondary structure.
IS
IS
In a B-pleated sheet, the side chains are located between adjacent segments.
Peptide bonds stabilize secondary structure.
The secondary level of protein structure refers to the spatial arrangements of short segments of the protein.
In an a-helix, the side chains are located on the outside of the helix.
The a-helix is held together by hydrogen bonds between the amide N-H and C=0 groups.
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QUESTION 4
Which of the following amino acids would stick to a CM-sepharose column at pH 7.07
Choose all that apply. Partial credit is allowed for each correct answer, arnd negative scores are allowed for incorrect answers.
O Arginine (pl -10.76)
O Glutamic acid (pl 3.22)
O Cysteine (pl 5.07)
O Histidine (pl 7.59)
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Which one of the following is NOT true about ECM?
O ECM is composed of an interlocking mesh of fibrous proteins and glycosaminoglycans.
O ECM supports cell-to-cell communication and stem cell differentiation.
O Proteoglycan complex has a unique bottle brush-like structure. It is positively (+) charged. It is composed glycosaminoglycans and carbohydrates that are attached to the proteins.
O ECM is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells.
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QUESTION 2
Which peptide will most strongly attach to a carboxymethyl ion exchange column at pH 7.4?
O N'-Glu-Lys-Arg-Asp-Tyr-C'
O N'-Tyr-Arg-Lys-Arg-Gly-C'
O N'-Gly-Glu-Gln-Asp-Asp-C'
O N'-Val-Ala-Leu-lle-Arg-C'
QUESTION 3
Which will be product of transcription from this double-stranded (ds) DNA sequence?
5' - atgttcaaagcctattcg - 3'
3' - tacaagtttcggataagc - 5'
O YKFRIS
O uacaaguuucggauaagc
O auauucaaaaccuauuca
Which will be product of transcription from this double-stranded (ds) DNA sequence?
5' -
atgttcaaagcctattcg – 3'
3' - tacaagtttcggataagc – 5'
O YKFRIS
O uacaaguuucggauaagc
O auguucaaagccuauucg
Ο MFKAYS
QUESTION 4
The
structure of hemoglobin consists of a 2a and 2B heterotetramer.
O quaternary
O tertiary
O secondary
O primary
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Question 6
What conformation of B subunits contributes to form ATP?
F1 conformation
O open conformation
loose conformation
tight conformation
O conformation
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Which of the following enzymes are involved in phosphorylation process
Question 8 options:
Lipases
Phosphatases
Proteases
Kinases
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5 pts
Question 9
95
58
40
HS
HS
SH
65
8 M urea and
72
B-mercaptoethanol
65
Hs84 Hs-
SH
72
26
HS
110 SH
84
26
110
95
124
40
58
Native ribonuclease
Denatured reduced ribonuclease
Figure 2.53
Biochemistry, Seventh Edition
O 2012 W. H. Freeman and Company
The image above shows how Anfinsen unfolded ribonuclease for his classic
experiment to see if proteins contain all necessary information for adopting
their folded states on their own. To achieve proper refolding and
ribonuclease activity, Anfinsen must have:
trick question: ribonuclease cannot adopt its folded state without the help of
cellular machinery
removed the mercaptoethanol followed by the urea
very carefully removed both the urea and mercaptoethanol at the same time
removed the urea followed by the mercaptoethanol
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Question 32
What will be the anticodons that will arrive in the translation of MRNA below? MRNA 5-
AAUAUGCGGAUGCCCGAA -3
O "AAU, AUG, CGG, AUG, CCC, GAA"
O "UAC, GCC, UAC, GGG, CAA"
O "AUG, CGG, AUG, CCC, GAA"
O "UUA, UAC, GCC, UAC, GGG, CAA"
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Question 1 (Mandatory) (
Phospholipids contain a glycerol backbone attached to two fatty acid hydrocarbon tails (often 18-20
carbons long), and a phosphate-containing polar group
True
False
Question 2 (Mandatory) (1 point)
Lipids are glycosylated in the Golgi (glycosylation), with oligosaccharides added on the lumen side
True
False
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Question 17
Which of the following are true regarding proteins? Select all that apply.
O the amino group is responsible for forming the peptide bonds when synthesizing proteins
O a mild increase in temperature may increase the kinetic energy of an enzyme and increase its function
O catabolism of proteins involves hydrolysis
Oa drastic change in pH will not affect the structuire but it will affect the function of a protein
O proteins are made up of chains of nucleotides
O the tertiary structure of a protein determines the function of the protein
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Related Questions
- Question 20 Signal sequences are often found at the C-terminus of the polypeptide chain. True False Question 21 Attachment of an isoprenid group to a protein to form a lipid-linked protein Palmitoylation Acetylation Prenylation Lipidation Question 22 Each GroEL subunit has an ATP-binding pocket that catalyzes hydrolysis of its bound ATP True False Question 23 Calnexin and calreticulin recognize lipid molecules covalently attached to proteins to assist proper folding and translocation O True O Falsearrow_forwardQuestion 4 Which of the following represents an example of a proteoglycan? attachment of several molecules of heparin to the peptide antithrombin II attachment of a Gal-B(1,3)-GalNAc disaccharide to the fish antifreeze protein attachment of a small oligosaccharide to an immunoglobulin O attachment of a small antigenic determinant to a membrane bound protein of a cellarrow_forwardQuestion 22 Each GroEL subunit has an ATP-binding pocket that catalyzes hydrolysis of its bound ATP True False Question 23 Calnexin and calreticulin recognize lipid molecules covalently attached to proteins to assist proper folding and translocation True Falsearrow_forward
- Question 8 Which statement about N-linked glycosylation is correct? O N-linked oligosaccharides are attached to proteins one sugar at the time in the endoplasmicreticulum. O N-linked sugars are attached to proteins as a 14 residue oligosaccharide during translation in the endoplasmic reticulum. O N-linked sugars are attached to proteins as a 14 residue oligosaccharide during translation inthe cytoplasm. O N-linked sugars are attached to proteins as a 14 residue oligosaccharide after translation inthe Golgi apparatus.arrow_forwardPDB code 7BSJ Questions Q1 - What is the name of the protein Q2 - What does the protein do? Q3 - What are the structural features of the protein? Q4 - What are two features of your protein’s structure that make it different OR similar to haemoglobin? Q5 - Based on the structural properties of your protein, how resistant (or sensitive) would your protein be to heat denaturation and why?arrow_forwardQuestion 14 The folding of an unfolded protein proceeds from low entropy disordered state to a single high entropy, low energy native conformation O True O False Question 15 The GroES subunit has 14 identical 549-residue subunits arranged in two stacked rings with 7 subunits eac True Falsearrow_forward
- QUESTION 1 A macromolecule binding to its ligand at 1x 10Mis considered weak binding. True O False QUESTION 2 For protein structure determined using X-ray difraction with the 1.1-Angatrom resolution, the electron density of the hydrogeon atoms becomes clearly visible True False QUESTION 3 In Creutzfeldt-Jakob disease, the native prion proteins that are alpha rich in the structure are mistolded to beta rich structures that nucleate to form an amyloid iber. These prion proteins are extremely stable at physiological temperatures True False QUESTION 4 is a high-pressure cell homogenizer used for generating cell lysate.arrow_forwardQuestion 1 Signal sequences direct their delivery to different locations in the cell or outside the cell True False Question 2 Which protein targeting pathway refers to the movement of polypeptides through the membrane as it is being synthesized? Proteolysis O removal of phosphoryl group O acetylation O None of the given Question 3 Molecular chaperones stabilize unfolded proteins and bind to protein in the native conformation O True Falsearrow_forwardBiological waxes are all Question 6 options: Cholesterol is a sterol that is commonly found in mammals. Sterols are precursors of steroid hormones. Sterols are more common in plasma membranes than in intracellular membranes (mitochondria, lysosomes, etc.). None of the answers are correct Sterols are commonly found in bacterial membranes.arrow_forward
- QUESTION 4 What percent are the following two 20 amino acid peptides similar? MTEKRVQDKAKLIVDEQACT MTDVRIQERTKLKVFEQLCI O 25% O 25% O 75% 90%arrow_forwardQuestion 9 Choose the CORRECT statement. O A polypeptide chain may have abrupt changes in direction and restriction in geometry because of the presence of glycine O A polypeptide chain may have abrupt changes in direction and restriction in geometry because of the presence of valine O A polypeptide chain may have abrupt changes in direction and restriction in geometry because of the presence of arginine O A polypeptide chain may have abrupt changes in direction and restriction in geometry because of the presence of prolinearrow_forwardQuestion 9 What structural features are true regarding the transmembrane and cytoplasmic domains? Choose all that apply a stretch of about 20 hydrophobic residues with non-conserved sequences is anchoring the transmembrane domain no non-catalytic sequences are found non-catalytic sequences are on both sides of the catalytic part of the protein no sequence similarity is found for the intracellular domainarrow_forward
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