1) During anaphase, Kinesin-13 proteins are localized at the kinetochore (A1) and the spindle pole (A2). While many kinesins can bind onto straight protofilaments and "walk" along the microtubule, studies have shown that the high-affinity binding site for Kinesin-13 family members is only on a curved protofilament. What is the significance of this? Why would Kinesin-13 only bind strongly with curved protofilaments? 2) What is the role of Kinesin-5 during anaphase (B1)? What would occur if kinesin- 5 "walked" towards the negative ends of the microtubules? 3) Astral microtubules (B2) aid in spindle orientation and position, a role facilitated by the association of dynein light chains (their tail) to the cell membrane. Explain the purpose of this association with the membrane, and how it may assist in cytokinesis.

1) During anaphase, Kinesin-13 proteins are localized at the kinetochore (A1) and the spindle pole (A2). While many kinesins can bind onto straight protofilaments and "walk" along the microtubule, studies have shown that the high-affinity binding site for Kinesin-13 family members is only on a curved protofilament. What is the significance of this? Why would Kinesin-13 only bind strongly with curved protofilaments? 2) What is the role of Kinesin-5 during anaphase (B1)? What would occur if kinesin- 5 "walked" towards the negative ends of the microtubules? 3) Astral microtubules (B2) aid in spindle orientation and position, a role facilitated by the association of dynein light chains (their tail) to the cell membrane. Explain the purpose of this association with the membrane, and how it may assist in cytokinesis.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter4: Cell Structure

Section: Chapter Questions

Problem 23RQ: The key components of desmosomes are cadherins and. actin microfilaments intermediate filaments...

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