16. The Type A Transferase enzyme, attaches N-acetylgalactosamine (GalNAc) to H-antigen epitopes; the Type B Transferase enzyme instead transfers galactose (Gal) to the H-antigen. Individuals with Type A blood thus have at minimum one copy of the active Type A Transferase, those with Type B have at minimum one copy of the active Type B Transferase, those with Type AB have one active copy of each, those with Type O have neither. Imagine an AB individual who acquires a mutation in their Type B Transferase gene that allows it to be active with either Gal or GalNAc. Make sure to include a brief justification for your answer to each question below. a. What blood type antigens would this individual express? b. If this individual had a child with a normal O partner, what possible blood type antigens could the child express? c. If this individual had a child with a homozygous dominant B partner (BB), what possible blood type antigens could the child express?
16. The Type A Transferase enzyme, attaches N-acetylgalactosamine (GalNAc) to H-antigen epitopes; the Type B Transferase enzyme instead transfers galactose (Gal) to the H-antigen. Individuals with Type A blood thus have at minimum one copy of the active Type A Transferase, those with Type B have at minimum one copy of the active Type B Transferase, those with Type AB have one active copy of each, those with Type O have neither. Imagine an AB individual who acquires a mutation in their Type B Transferase gene that allows it to be active with either Gal or GalNAc. Make sure to include a brief justification for your answer to each question below. a. What blood type antigens would this individual express? b. If this individual had a child with a normal O partner, what possible blood type antigens could the child express? c. If this individual had a child with a homozygous dominant B partner (BB), what possible blood type antigens could the child express?
Chapter14: Allergy: An Overview
Section: Chapter Questions
Problem 23RQ
Related questions
Question
![16. The Type A Transferase enzyme, attaches N-acetylgalactosamine (GalNAc) to
H-antigen epitopes; the Type B Transferase enzyme instead transfers galactose
(Gal) to the H-antigen. Individuals with Type A blood thus have at minimum one
copy of the active Type A Transferase, those with Type B have at minimum one
copy of the active Type B Transferase, those with Type AB have one active copy
of each, those with Type O have neither. Imagine an AB individual who acquires a
mutation in their Type B Transferase gene that allows it to be active with either
Gal or GalNAc. Make sure to include a brief justification for your answer to each
question below.
a. What blood type antigens would this individual express?
b. If this individual had a child with a normal O partner, what possible blood
type antigens could the child express?
c. If this individual had a child with a homozygous dominant B partner (BB),
what possible blood type antigens could the child express?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F96c3fa8a-2d55-4155-912c-543527caa76e%2Fb3e1170d-ecc9-44e3-b858-5aa07b909a91%2Fd2h4ct_processed.png&w=3840&q=75)
Transcribed Image Text:16. The Type A Transferase enzyme, attaches N-acetylgalactosamine (GalNAc) to
H-antigen epitopes; the Type B Transferase enzyme instead transfers galactose
(Gal) to the H-antigen. Individuals with Type A blood thus have at minimum one
copy of the active Type A Transferase, those with Type B have at minimum one
copy of the active Type B Transferase, those with Type AB have one active copy
of each, those with Type O have neither. Imagine an AB individual who acquires a
mutation in their Type B Transferase gene that allows it to be active with either
Gal or GalNAc. Make sure to include a brief justification for your answer to each
question below.
a. What blood type antigens would this individual express?
b. If this individual had a child with a normal O partner, what possible blood
type antigens could the child express?
c. If this individual had a child with a homozygous dominant B partner (BB),
what possible blood type antigens could the child express?
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