OH -% OH OH H₂ HO HN, OH Figure 1 Structure of TTX Na-OH₂ on Channel Membrane Jon Chamel Tetrodotoxin Figure 1 Binding of TTX to Sodium channel www.www. www.www www.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal transmission. Propose a computational research project in which you would use TTX as a starting material to design a painkiller (an analgesic drug). Note the following: (50 Marks) You must clearly mention the computational methods/techniques and their significance in this research. Sodium channel Nv1.7 is a transmembrane protein. • TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This is schematically represented in Figure 2. Strong Painkillers partially/ irreversibly block Na channels.
OH -% OH OH H₂ HO HN, OH Figure 1 Structure of TTX Na-OH₂ on Channel Membrane Jon Chamel Tetrodotoxin Figure 1 Binding of TTX to Sodium channel www.www. www.www www.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal transmission. Propose a computational research project in which you would use TTX as a starting material to design a painkiller (an analgesic drug). Note the following: (50 Marks) You must clearly mention the computational methods/techniques and their significance in this research. Sodium channel Nv1.7 is a transmembrane protein. • TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This is schematically represented in Figure 2. Strong Painkillers partially/ irreversibly block Na channels.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
Related questions
Question
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
Recommended textbooks for you
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY