Answered: Figure Q13-3 A normal mouse and the…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question

Melanosomes are specialized lysosomes that store
pigments for eventual release by exocytosis. Various cells
such as skin and hair cells then take up the pigment, which
accounts for their characteristic pigmentation. Mouse
mutants that have defective melanosomes often have pale
or unusual coat colors. One such light-colored mouse, the
Mocha mouse (Figure Q13–3), has a defect in the gene for
one of the subunits of the adaptor protein complex AP3,
which is associated with coated vesicles budding from the
trans Golgi network. How might the loss of AP3 cause a
defect in melanosomes?

Figure Q13-3 A normal
mouse and the Mocha
mouse (Problem 13-11).
In addition to its light
coat color, the Mocha
mouse has a poor sense
of balance. (Courtesy of
Margit Burmeister.)
normal mouse
Mocha mouse

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