Generally, polysaccha are not good antigenS, because B cells recognize thei annot get T-cell help. But for some pathogens, such as Streptococcus pneumoniae opsonization by antibodies that bind the thick polysaccharide "capsule" layer surrounding the bacteria is the major mechanism of clearing the infection. As expected, a pure polysaccharide vaccine is not terribly effective, but much better immunity is achieved by vaccinating with a polysaccharide covalently linked "conjugated" to an unrelated protein. Explain how this conjugate vaccine allows B cells capable of making anti-polysaccharide antibodies.
Generally, polysaccha are not good antigenS, because B cells recognize thei annot get T-cell help. But for some pathogens, such as Streptococcus pneumoniae opsonization by antibodies that bind the thick polysaccharide "capsule" layer surrounding the bacteria is the major mechanism of clearing the infection. As expected, a pure polysaccharide vaccine is not terribly effective, but much better immunity is achieved by vaccinating with a polysaccharide covalently linked "conjugated" to an unrelated protein. Explain how this conjugate vaccine allows B cells capable of making anti-polysaccharide antibodies.
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter17: Genes And The Immune System
Section: Chapter Questions
Problem 31QP
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