HeLa cells are a line of cells grown in laboratory culture that has been used extensively in research. This cell line was originally derived from malignant cervical cancer cells that were removed from a woman named Henrietta Lacks in 1951. They were grown in culture and shipped to research labs around the world where they have been used in many important experiments. Like HeLa cells, many other cell lines were originally taken from cancerous tissue. What are the advantages to using cancer cells for developing cell lines? Why not use normal tissue?

HeLa cells are a line of cells grown in laboratory culture that has been used extensively in research. This cell line was originally derived from malignant cervical cancer cells that were removed from a woman named Henrietta Lacks in 1951. They were grown in culture and shipped to research labs around the world where they have been used in many important experiments. Like HeLa cells, many other cell lines were originally taken from cancerous tissue. What are the advantages to using cancer cells for developing cell lines? Why not use normal tissue?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section12.10: Genomics, Epigenetics,and Cancer

Problem 2GR: Another model, the random model, proposes that any cell in a malignant tumor has the potential to...

See similar textbooks

Similar questions

New treatments for several conditions are being developed using stem cells in medical waste, such as biopsy material, teeth, menstrual blood, umbilical cords, and fatty tissue removed in liposuction. For example, fat samples from injured horses are used to grow stem cells to treat tendon injuries. Explain how the two defining characteristics of stem cells enable them to be used to replace damaged or diseased tissue, so that the new tissue functions as opposed to forming a scar.
I am confused about how stem cell transplants works. If you put a semi differentiated tadpole nucleus in a denucleated egg cell, it’ll develop into a fully formed tadpole, but if you put a fully differentiated tadpole nucleus, it won’t (because the genes have already been expressed in a way where the cytoplasmic determinants cannot operate to the fullest). Then how come in stem cell transplants, you use adult nucleuses that are already developed and transplant them into the denucleated egg cells?
HeLa Cells are the most widely used human cell line. They have been used in thousands of studies, leading to countless discoveries. These cells were unknowingly taken from Henrietta Lacks, a Johns Hopkins Medical Center patient. Dr. Gey at Johns Hopkins Medical Center took some of the cells from Mrs. Lacks's cancer and discovered that they could keep growing and dividing indefinitely. Mrs. Lacks did not know these cells were taken from her and neither did any of her family members. Today, strict guidelines protect individuals participating in a federally funded research study (e.g., in a clinical trial). The study has to go through a lengthy review and participants receive information about all aspects of the study and provide “informed consent” to participate. These guidelines are known as the Common Rule. However, the Common Rule does not apply to cells or tissues removed during medical procedures. Scientists can use leftover tissues from surgeries, and biopsies for research…
Cell division cycle mutations render the mutants unable to continue the cell cycle. This phenotype creates a paradox where mutant cells must also be grown in the lab to further identify the gene and study the role of the protein. How do you think this problem can be solved?
Why would the failure of the p53 tumor supressor gene be more likely to cause cancer in a seventy year old person compared to a ten year old person? Group of answer choices A) The seventy year old is more likely to have pre-existing failures in cell cycle control B) cells divide more rapidly as people get older C) there are fewer mutations in genes controlling the cell cycle in older people D)the p53 gene never works well in old people
Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell would divide when it is not supposed to, increasing the chance that it would become cancerous. CHOOSE ALL THAT APPLY. A) A tumor suppressor gene is over-expressed B) A cyclin gene is mutated so that it is expressed at all times during the cell cycle C) A cyclin-dependent kinase gene is mutated so that in the Cdk is no longer dependent on its cyclin D) A Cdk gene is mutated so that the Cdk protein is not made E) Mutation of an oncogene that causes it to no longer be expressed F) A proto-oncogene gene is expressed at higher than normal levels G) The p53 gene is mutated so that no p53 protein is made
What separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.
Many cell lines used in medical research were originally derived from cancerous tissue. Why are cancer cells often used for developing cell lines?
One important biological effect of a large dose of ionizing radiation (like X-rays) is to halt cell division. How does this occur? To answer this question, state the name and role of 2 specific and important proteins involved in the process. What happens if a cell has a mutation that prevents it from halting cell division after be irradiated? Be specific and detailed. An adult human who has reached maturity will die within a few days of receiving a radiation dose large enough to stop cell division. What does that tell you about cell division? In addition, name 2 different/unique cell types that would be primarily affected.
A protein called p53 is another protein involved in controlling cell division. The protein p53 makes sure that if cells aren't functioning correctly, they don't divide anymore. Some people have damage to their p53 DNA and the protein isn't made correctly anymore. What might be a consequence if a person couldn't make the protein p53? A - Their cells would no longer use oxygen to make energy B - Their cells would no longer divide C - Their cells would make too much carbon dioxide D - Their cells could divide out of control
one question with multiple parts! 1A) If you were a cancer biologist interested in developing new drugs that will slow down cancer cell metastasis, which of the following strategies would be most effective? a)Develop an activator of mitosis b)Make Her2 protein that is more active on the surface of the cancer cells c) Develop a molecule that increases telomerase activity d) Gene therapy to add a mutated p53 gene to the cancer cells 1B) You are a genetic counsellor, and a couple comes to you with concerns that if they have a child together the child could have the X-linked recessive disease Duchene muscular dystrophy. The man has the disease whereas the woman is a carrier. Which of the following would be a true statement to tell them? a) 100% of their male offspring will likely be carriers of the recessive allele that causes the disease b) 75% of their female offspring will likely be carriers of the recessive allele that causes the disease c) 100% of their male offspring will likely…
What are stem cells? Which stem cell treatment can form a benign tumor? Please explain how benign tumor can form from the stem cell therapy?