II. While there are many different types of inhibitors, most have a very similar structure so they can compete with the normal substrate (in this case dopamine). Of the molecules below, which compound do you think has the most promise as an inhibitor? HO a.a.#1 N- H a.a.#2 H₂PO3 -PO₂H₂ OH Alendronate a.a.#6 NH₂ Carbidopa Using the same, amino acid orientation as you arrived at for Part I, show which inhibitor is most promising a.a.#5 Raloxifene a.a.#3 a.a.#4
Q: The protein catalase catalyzes the reaction described by 2H₂O₂(aq) → 2H₂O)+O₂(g) and has a…
A: Km (Michaelis–Menten constant) = The substrate concentration at which the reaction velocity is half…
Q: 4. ANSWER THE FOLLOWING PROBLEM AND EXPLAIN YOUR ANSWER FOR BETTER UNDERSTANDING. Which of the…
A: Amino acids are the building blocks of proteins. There are 20 amino acids which are called general…
Q: rostaglandin synthase converts which molecule into prostaglandin H2? ____________ Movement of a…
A: The biological membrane that surrounds a living cell is called the cell membrane. The structure of…
Q: This drug resembles proteins that are cut by enzymes that use water to break amide linkages in…
A: Enzymes are biological catalysts that increase rate of biochemical reactions.Enzymes are mostly…
Q: Classify the phrases. Does each phrase describe a kinase, a phosphatase, neither, or both? Kinases…
A: Proteins are regulated by adding or removing phosphate groups. These are crucial for the…
Q: You discover a new organism that contains enzyme that can break down beta(1,4) glycosidic linkages,…
A: There are four classes of biological macromolecules; proteins, nucleic acid, lipids and…
Q: What are the main products of anaerobic glycolysis? Hoe does each one get metabolized?
A: Anaerobic glycolysis is defined as a metabolic process which takes place when oxygen is not present…
Q: As described in 4C above, PLP-dependent enzymes can generate formaldehyde from serine. This compound…
A: Protonation/deprotonation is a common step in biochemical reaction. Enzymatic reactions can proceed…
Q: Select the statements that are true about the w-3 fatty acids and w-6 fatty acids. The w-3 fatty…
A: There are four classes of biological macromolecules- they are nucleic acid, proteins, lipids and…
Q: Model 1 Model 1 Idealized Graphs of Enzyme inhibition Competitive Inhibition FEE Inh. slope How does…
A: Since you have posted multiple questions, we will provide the solution only to the first question as…
Q: 1. What type of reaction occurred when the samples (enumerated) reacted with the Molisch reagent?…
A: As per Bartelby guidelines, an expert cannot answer more than one question. Kindly submit other…
Q: Which of the following are features of facilitated diffusion? Select all that apply. lon transport…
A: Facilitated diffusion is a passive transport process in which molecules or ions move across a…
Q: A contributing factor to the development of arthritis is the inappropriate proteolytic destruction…
A: A variable is any quantity we can measure. In any experiment there are three variables: Independent:…
Q: Choose the Incorrect statement. In the phospholipid bilayer part of the cell membrane. None of the…
A: The cell membrane is composed of a phospholipid bilayer that plays a crucial role in various…
Q: is the sum of all chemical reactions in the body. It allows the body to convert energy from oods…
A: Metabolism is a fundamental and intricate biochemical process that underpins the functioning of…
Q: For a reaction that proceeds spontaneously from reactants to products, the AG is O less than 0 00 O…
A: Gibbs Free Energy is a thermodynamic function that not only is related to spontaneity but also deals…
Q: 200 microliters of a standard solution of 0.200 mg/mL caffeine was mixed with 4.8 mL of 50 mM sodium…
A: Equation of dilution: M1 × V1 = M2 × V2where:M1 is the molar concentration of the stock solution.M2…
Q: Can you explain the various options and how did you come to the answer? How to determine when…
A: Weak acids are the acids that do not completely dissociate into their constituent ions when…
Q: 1. Provide a reasonable step-wise mechanism for the reaction below, involving FAD as a coenzyme and…
A: Each cycle of fatty acid oxidation in cellular mitochondria begins with the catalysis of an enzyme…
Q: 1. You are studying the kinetic behavior of the enzyme aldolase, which converts the substrate,…
A: For a one-substrate enzyme-catalyzed reaction, the Michaelis-Menton equation shows the quantitative…
Q: What is the concept of FoldIt protein folding game, and how is it used to elucidate and visualize…
A: The Department of Biochemistry and the Center for Game Science at the University of Washington…
Q: The following diagram shows reaction curves for aspartate transcarbamoylase (ATCase) with…
A: Allosteric enzyme is the class of regulatory enzyme which increases or decreases catalytic activity…
Q: For the same drug, what amino acids of an active site of an enzyme would interact with one of the…
A: As we know that, hydrogen atom is electropositive atom, hence it will bond to the electronegative…
Q: Which of the equations below best represents how excess acid in the blood plasma can be removed in…
A: All biological processes are pH dependent. Even a slight change in pH can result in a large change…
Q: TABLE 5.1 Properties of the common amino acids found in proteins Name Alanine A, Ala Arginine R, Arg…
A: Proteins are folded peptides. Peptides of chain of amino acid residues linked together via a peptide…
Q: Which of the following statements is WRONG with regard to the following molecule?
A: A cell is the basic structural and functional unit of life where all the metabolic activities are…
Q: What metabolic pathways are aerobic and which are anaerobic? What are the advantages and…
A: A living organism's total chemical reactions are referred to as its metabolism. It incorporates…
Q: What might happen to someone if their cells no longer recognized ghrelin's message? they would never…
A: Ghrelin is a hormone produced mainly by the stomach and, to a lesser extent, by other tissues in the…
Q: The concentrations of ATP, ADP, and P; differ with cell type. Consequently, the release of free…
A: Since conditions inside the cell are different than standard temperature and pressure, biochemists…
Q: Match the structures below with the type or name of the structure. Each match should be used only…
A: Triglycerides are esters, made up of a glycerol molecule bound to three fatty acid moleculesFatty…
Q: You fill a (fixed volume) dialysis bag with a solution of a protein (1 mM) in water, seal the…
A: Dialysis tubing can be defined as a semi permeable membrane tubing is particularly used in…
Q: select the false statement regarding phospholipid bilayer membranes. phospholipid bilayer part…
A: A cell is made up of different biomolecules. Biomolecules are of four types: carbohydrates,…
Q: Which is true of reducing disaccharidess: a) One sugar has an unlinked anomeric carbon b) the…
A: Since you have posted multiple multiple choice questions, we will provide the solution only to the…
Q: Frog muscle cells and the solution bathing the cells contain ions at different concentrations. The…
A: Inside the cell, the most abundant ions is K+ (potassium). Therefore for the calculation of membrane…
Q: Which of the outcomes could potentially result if a mutation in the gene encoding the Ga subunit…
A: Heterotrimeric G protein is a complex comprised of 3 protein subunits;, and . They are often…
Q: Which of the following statements about 2,3-bisphosphoglycerate (2,3-BPG) are true? 2,3-BPG lowers…
A: A three-carbon chemical compound called 2,3-bisphosphoglycerate (2,3-BPG) is involved in the…
Q: yruvate carboxylase catalyzes the first step of gluconeogenesis. ATP + HCO3─ + pyruvate →…
A: Actual free energy change is related to standard free energy change by the following mathematical…
Q: You begin to study enzyme Z, which catalyzes a simple reversible reaction that interconverts…
A: S to P conversion is said to have a of -6 kJ/mol. So, let's give 'S' a free energy (G) value of 0…
Q: R dy O -D 117 9, 1811 5 96 OF fa -Only-
A: Answer :- A vital physiological mechanism that aids in keeping our blood's pH within a certain and…
Q: what are the non-regulatory enzymes involved in glycolysis.
A: Glycolysis is the 10-step enzymatic oxidation of a single glucose molecule into two molecules of…
Q: Which of the following statements describes one reason that plant oils are generally healthier for…
A: Plant oils are liquid fats extracted from various plant sources, such as seeds, nuts, and fruits.…
Q: Which of the following are roles of the distal histidine in hemoglobin? to help to keep the heme in…
A: The distal histidine in hemoglobin plays a crucial role in its functioning. Let's analyze the…
Q: 1) Phosphatidate composed of octadecanoate fatty acids 2) Phosphatidate composed of hexadecanoate…
A: The graph given below shows the fluidity of membrane. The degree of bilayer fluidity depends on…
Q: 6 9 ation Which of the following is an unacceptable structure of a monosaccharide sugar? А. C. HOCH2…
A: Monosaccharides are the most simple sugars/carbohydrates. These are composed of carbon, hydrogen and…
Q: Assume that the complete combustion of one mole of glucose to carbon dioxide and water liberates…
A: Given:Complete combustion of one mole of glucose liberates 2870 kJ.ΔG° = -2870 kJ/mol Efficiency of…
Q: Analyze the following pair of compounds. Which of the terms explains the relationship between the…
A:
Q: Which of the following vitamins do you expect to enter the cell via diffusion (i.e., NOT need a…
A: Diffusion refers to the movement of a substance from a region of higher concentration to a region of…
Q: which region (ribose or base) could be modified to create an inhibitor ?
A: Inhibitors are the molecules or substances that result in inhibiting (stopping) the chemical or…
Q: Glucose generally exists in ring (cyclic) form. A Haworth projection shows the orientations of the…
A: Glucose is a monosaccharide and classified as an aldohexose since it contain 6 carbon atoms along…
Q: Which of the following statements about 2,3-bisphosphoglycerate (2,3-BPG) are TRUE. 2,3-BPG lowers…
A: Let's assess each statement to determine which ones are true:1. 2,3-BPG lowers the affinity of…
Step by step
Solved in 3 steps
- Od. Vitamin B2 s page Hexokinase catalyzes phosphorylation of glucose to clucose-6-phosphate, where ATP is used as a donor of phosphate group, this an example of: Select one: NAVIGATION a. Oxidoreductase b. Ligase c. Lyase d. Transferase Next page. Radioactive uracil can be used to label all of the pyrimidine residues in DNA. Using either names or structures, present pathways for the conversion of uracil to dTTP and to dCTP. For each reaction, show the involvement of cofactors, and identify sites of allosteric regulation.5. You discover a new cysteine protease similar to papain. Cysteine proteases are proteolytic enzymes that utilize a cysteine residue in the active site for the nucleophilic attack of a peptide bond, while a second residue acts as a base for proton abstraction in the reaction (acid base catalysis). In this novel enzyme the pKa of the cysteine residue is significantly lowered by the active site environment to pKa=4. a. Knowing that the protease shows highest activity between pH 4-6, what could be the identity of the base residue acting as a in the reaction? Explain and write the expected mechanism for the reaction. SH он
- Hi, help please. Discuss each method of regulating phosphofructokinase below as indicated by the circle. Discuss 1.) The type of regulation occurring, 2.) What compound or condition performs the regulation, 3.) How/why it influences the enzyme activity.. Propose a chemical mechanism for the reaction catalyzed by the PLP-dependent glatamate 1-semialdehyde aminomutase.a. Protein X can be phosphorylated. Why would the phosphorylated form of protein X elute AFTER the unphosphorylated form from an ANION exchange column? Please describe in terms of: The chemical properties of phosphorylation modification b. The chemical properties of an anion exchange column and how it works c. Why is an inhibitor that mimics the transition state more effective at enzyme inhibition than an inhibitor that mimics the substrate? d. Protein X can be covalently modified with many methyl groups. What two general properties would be different between the unmethylated protein versus the methylated protein?
- IX. Insulin, a hormone vital in blood sugar regulation and having a polypeptide chain with disulfide linkages, loses its regulatory activity when heated at nearly 100°C for 5-10 minutes. Explain the molecular basis of this observed thermal property of insulin relative to its native structure and function. I--Required partner. Aminotransferases require which of the following cofactors: a. NAD+/NADP+NAD+/NADP+ b. Pyridoxal phosphate c. Thiamine pyrophosphate d. BiopterinA. Lineweaver-Burk plot of the enzyme with increasing amounts of substrate in the absence or the presence of the inhibitor is shown below. Graph A : x-intercept Graph B : x-intercept = - 0.012, y-intercept = 0.8 Graph C : x-intercept = - 0.027, y-intercept = 0.8 Graph D : x-intercept = - 0.039, y-intercept = 0.8 - 0.007, y-intercept = 0.8 Graph A 4 Graph B Graph C Graph D 1 -0,04 -0,02 0,00 0,02 0,04 1/[Substrate] (uM) (i) Which graph indicates an enzymatic reaction without inhibitor? (ii) Which type of inhibitor is it? Briefly explain. (iii) Which graph indicates the highest concentration of inhibitor? (iv) Calculate the Vmax and Km of the graph showing an enzymatic reaction with the lowest concentration of inhibitor. Show the steps of calculation and unit in your answers. Keep 2 decimal places in your answers. 1/Rate (umol/min)
- A7. Consider what can be concluded about the catalytic site (substrate binding site) of phosphatase and the binding site of NaF from the type of inhibition shown by NaF for phosphatase and illustrate it schematically. The inhibition typre is pure noncompetitive inhibition.Regulation of enzyme activity 1. Allosteric control 2. Covalent modification (on/off switch) 3. Proteolytic cleavage 4. Isoenzymes 5. Genetic control (transcription regulation) (enzyme level) How do these types of regulation impact the biochemical processes they regulate?In full details. Define 'activation energy' of an enzyme catalysed single substrate reaction and mention the effects of an enzyme on this energy.