OPh OPh D CI Br N E N Но o-SiMeg OH OPh OPh F NH2 Но N Но OH OH A v ( Choose )

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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OPh
OPh
D
CI
Br
N
E
N
Но
o-SiMeg
OH
OPh
OPh
F
NH2
Но
N
Но
OH
OH
A
V ( Choose ]
Bu4N+ F-
МСРВА (Ваyer villager)
Mg, then CO2 (Kobe!!!!)
NH3 (SNAR)
H2S04, Heat (Fisher esterification)
03, DMS (ozonalysis)
Choose
(Choose )
E
[ Choose )
F
[ Choose )
B.
Transcribed Image Text:OPh OPh D CI Br N E N Но o-SiMeg OH OPh OPh F NH2 Но N Но OH OH A V ( Choose ] Bu4N+ F- МСРВА (Ваyer villager) Mg, then CO2 (Kobe!!!!) NH3 (SNAR) H2S04, Heat (Fisher esterification) 03, DMS (ozonalysis) Choose (Choose ) E [ Choose ) F [ Choose ) B.
The kinase ITK is a key regulator of T-cell proliferation and differentiation, and inhibition of ITK is
thought to be a therapeutic approach for T-cell cancers and inflammatory diseases. Bahar is working
on the design and synthesis of selective ITK inhibitors, with some potential steps below. please
match the reactions with the appropriate reagents.
OPh
OPh
H H
A
HH
`N'
Он
N'
OH
OPh
OPh
H.
`N-H,
HH
B
N
H
НО
'N'
OH
ÓH
OPh
OPh
H.
'N-H
HH
N
но
'N-
OH
Transcribed Image Text:The kinase ITK is a key regulator of T-cell proliferation and differentiation, and inhibition of ITK is thought to be a therapeutic approach for T-cell cancers and inflammatory diseases. Bahar is working on the design and synthesis of selective ITK inhibitors, with some potential steps below. please match the reactions with the appropriate reagents. OPh OPh H H A HH `N' Он N' OH OPh OPh H. `N-H, HH B N H НО 'N' OH ÓH OPh OPh H. 'N-H HH N но 'N- OH
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