Suppose that the circulating concentration of hor-mone is 10–10 M and the Kd for binding to its receptor is 10–8M. What fraction of the receptors will have hormone bound?If a meaningful physiological response occurs when 50% ofthe receptors have bound a hormone molecule, how muchwill the concentration of hormone have to rise to elicit aresponse? The fraction of receptors (R) bound to hormone(H) to form a receptor–hormone complex (R–H) is [R–H]/([R] + [R–H]) = [R–H]/[R]TOT = [H]/([H] + Kd).

Suppose that the circulating concentration of hor-mone is 10–10 M and the Kd for binding to its receptor is 10–8M. What fraction of the receptors will have hormone bound?If a meaningful physiological response occurs when 50% ofthe receptors have bound a hormone molecule, how muchwill the concentration of hormone have to rise to elicit aresponse? The fraction of receptors (R) bound to hormone(H) to form a receptor–hormone complex (R–H) is [R–H]/([R] + [R–H]) = [R–H]/[R]TOT = [H]/([H] + Kd).

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter17: The Endocrine System

Section: Chapter Questions

Problem 1ILQ: Visit this link (http://openstaxcollege.org/l/hormonebind) to watch an animation of the events that...

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