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Why are chromosomal abberations considered to have less significance than gene mutations for subsequent generations?
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- what is the significance of chromosomal aberration? what are the different types of chromosomal abberations based on the structure and number of chromosomes? give examples for each. what environmental factors may increase in the incidence of chromosomal aberrations?What are chromosomal islands? Why are theyconsidered to be of foreign origin?Theodor Boveri predicted that malignancies would often be associated with chromosomal mutation. What lines of evidence substantiate this prediction?
- Why dominant negative mutation shows the haploinsufficiency ?Describe a chromosomal deletion, duplication, translocation, and inversion.12) An individual with genotype AaBbCCDdEE can make many kinds of gametes. Which of the following correctly describes why this situation is possible? A) recurrent mutations form new alleles B) crossing over during prophase I leads to genetic variety C) different possible assortment of chromosomes/alleles into gametes occurs D) there is a tendency for dominant alleles to segregate together 13) Let P = purple
- a) What is the chromosomal abnormality associated with Fragile-X Syndrome? b) What is the phenotype associated with this disorder? c) How is this trait inherited?Describe how different types of chromosomalrearrangements generate new gene products.What are the possible effects of chromosomal rearrangements?
- explain why Chromosome Loss CausesMosaicismWhat is the mechanism of generating aneuploiding A) Mitotic unequal segregation of chromatidsB)Meiotic nondisjunction of chromosomesC) Mitotic nondisjunction of chromosomal pairsAn individual has a deletion of part of the short arm of chromosome 5. This individual also has a normal copy of chromosome 5. Would you expect this individual to have Cri-du-chat syndrome? Why or why not? Question 7 options: A) Yes, because they will inactivate their normal chromosome 5 B) Yes, because they only contain one copy of some of their genes C) No, because this is a terminal deficiency D) No, because they still have at least one copy of all the genes on chromosome 5
