Write two paragraphs that describe how phosphofructokinase-1 and fructose 1,6-bisphosphatase are regulated in a coordinated and reciprocal manner. The first paragraph should describe how the enzymes are regulated in response to energy needs in muscle cells. The second paragraph should describe how the hormones glucagon and insulin exert their effects via fructose 2,6-bisphosphate in liver cells.

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