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- What is Down's syndrome? Give its symptoms and cause. Why is it that the chances of having a child with Down's syndrome increases if the age of the mother exceeds forty years?A form of hemophilia is caused by a sex-linked (X-linked) recessive gene. A phenotypically normal woman whose father had hemophilia marries a man who suffers with hemophilia. What is the probability that their first daughter will have hemophilia?Hemophilia is determined by genes on the X chromosome in humans. Assume that a phenotypically normal woman whose father had hemophilia is married to a normal man. 1) What is the probability that their first son will have hemophilia? 2) What is the probability that their first daughter will have hemophilia?
- Hemophilia A, a condition in which blood does not clot properly, is a recessive trait located on the X chromosome (Xh). A woman heterozygous for the trait marries a normal male. What is the probability that this couple will have hemophiliac daughters? What is the probability that this couple will have hemophiliac sons?Neurofibromatosis-1 (NF1) is an autosomal dominant disorder where tumours form in the base layer of the skin or in nerve tissues. What is the probability that individuals II-1 and II-2 will have a genetic son with NF1? Find the image attached.Why doesn’t the father (II-1) have the disease breast cancer? What is the formal name for an individual having the gene but not showing the trait?
- A man with thalassemia minor marries a normal woman. What phenotypic ratios of thalassemia-affected children might these parents expect?A haemophilic man marries a normal homozygous woman. What is the probability that their daughter will be haemophilic?Hemophilia A is caused by a recessive X-linked allele that encodes a defective form of a clotting protein. If a affected father and a mother who is known to not be a carrier have children, what percentage of female offspring will have hemophilia?
- Ch. 14-3 Marfan syndrome (Section 13.5) ) is inherited in an autosomal dominant pattern. What is the chance that a child will inherit the associated allele if one parent does not carry it and the other is heterozygous?Ch. 14-9 Mutations in the genes for clotting factor VIII and IX cause hemophilia A and B, respectively. A woman may be heterozygous for mutations in both genes, with a mutated factor VIII allele on one X chromosome, and a mutated factor IX allele on the other. All of her sons should have either hemophilia A or B. However, on rare occasions, one of these women gives birth to a son who does not have hemophilia, and his one X chromosome does not have either mutated allele. Explain.If diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this an indication that there is a genetic contribution to these traits? What would you do to confirm that genetics is involved in this condition?