Rheumatoid Arthritis Research

Rheumatoid arthritis is a chronic, systemic inflammatory autoimmune disease. The disease happens when the immune system mistakenly attacks a healthy tissue as if it was a foreign invader, such as a virus or bacteria. If left untreated it can lead to permanent joint damage, decrease in quality of life, and total disability. It affects over a million people in the U.S. alone. Rheumatoid arthritis symptoms include persistent joint inflammation which causes joint pain, stiffness, and swelling. Fatigue and stiffness are usually early symptoms. Joint pain can be an early symptom in a variety of diseases. Symptoms of rheumatoid arthritis often develop slowly over a period of weeks or longer, but this is not always the case, it can have an acute

As an autoimmune disease, the synovial cells are affected and causes synovial membrane and joint damage because synovial fibroblast and the immune response initiates the release of cytokines, enzymes, prostaglandins that cause synovial tissue to thicken and loss of bone due to an abnormality in the immune response that causes a condition called synovitis (Huether & McCance, 2017). Because the signaling immune pathway is altered in the processes it causes additional inflammation, enzymes migration to the area, and ingrowth of blood vessels that allow more fibroblast to be able to travel to ligaments, tendon, other fibrous joint located throughout the body that contributes to its systemic effect (Huether & McCance, 2017). As a result of this process, inflammation spreads to surrounding ligaments, tendons, and affected joints and people experience joint pain, decrease mobility, and deformity (Huether & McCance,

Thank you Prianca for taking the time to share about the cytokines and their interaction in the inflammatory process of the Rheumatoid Arthritis. Indeed, the epidemiology incidence of Rheumatoid arthritis (RA) is increasing every minute. Like you well explain above in your post, we have more than 1.3 million of people in the US affected with RA (Ruderman & Tambar, 2013) and 1 percent of the worldwide population is affected with RA (Lubberts & Berg, 2003). It seems like this epidemic is going to continue. 75 percent of that 1.3 million are women, and statistically, 1 of 3 women may get rheumatoid arthritis in their life. Rheumatoid arthritis can affect anybody at any age, but in most of the cases, the disease begins in the 40’s and 60’s (Ruderman & Tambar, 2013).

Rheumatoid arthritis (RA) is an autoimmune disease that affects the cartilage in one 's joints, it is not curable, it can not be stopped, only the pain itself can be lessened. In an average person’s body, the immune system has one job; to attack foreign substances that may enter the body. With the 1.5 million people in the United States that have been diagnosed with rheumatoid arthritis, their bodies are “tricked” or mislead into thinking that the cartilage within their joints is what is foreign. Once their immune system attacks the joints, it causes inflammation within, which then in turn leads to the synovium (lining of the joints) tissue to thicken. The synovium makes a fluid that acts as a lubricant to the joints and helps everything move freely. Once that fluid is gone, swelling and pain is experienced next. After awhile, the cartilage within the joints begins to disintegrate and will eventually cripple the individual. Along with knowing exactly what RA is, by the end of this paper you will know signs and symptoms within the oral cavity and systemically, and you’ll be familiar with how nutrition is related to the progression of this disease.

Rheumatoid arthritis is an autoimmune disease. normally the body’s immune system attacks and protects the body against foreign substance, with RA the immune system accidently attacks the joints. When the joints are mistakenly attacked inflammation occurs which causes the tissues to thicken thus resulting in pain and swelling of the joints. When this inflammation is undetected damage to the cartilage can occur, when this happens the spacing between the bones become smaller, the joints may become loose, painful, unstable and may also lose their mobility and deformity of the joints can occur.

Since rheumatoid arthritis is a systemic disease, it can also affect other organs and tissues, but it primarily attacks the joints in a symmetrical fashion. Rheumatoid arthritis develops from an abnormal immune response caused by exposure to an antigen, in a patient that is genetically susceptible. Autoantibodies develop and attack the patient’s cartilage and synovial tissues once the antigen exposure has occurred (Nelson, 2011). One of the most common

Rheumatoid arthritis is an autoimmune disease and is a chronic type of arthritis that occurs in the joints. RA is autoimmune disease where the immune system is not working properly and in the case of RA involves one’s immune cells attacking healthy joint tissue. Symptoms of this condition include joint pain, joint swelling, stiffening of the joints after long periods of inactivity and/or sitting, rheumatoid nodules, flare ups and fatigue. If someone is diagnosed with RA they will have to live with the condition for the rest of their life and instead of looking for a “cure” should find ways to manage their condition so they can live more comfortably. Fortunately there are many options of treatment to choose from for RA patients.

Rheumatoid arthritis is a disease that affects mostly joints, but can also spread to or affect vital organs such as the eyes, lungs, heart, and others. The disease is treatable to a degree, and if caught in early stages it can be easy to reduce inflammation and swelling in the afflicted areas. After reading this paper one should expect to better understand the symptoms of rheumatoid arthritis, causes of the disease, possible treatments, and ways to help prevent it. Nearly one and a half million (1,500,000) people in the United States are affected by rheumatoid arthritis, and three times as many women have the disease as men.

Rheumatoid arthritis is an autoimmune etiology that affects the patient in ways like, progressive disability, systemic complications, socioeconomic costs, and premature death. No cause, to date, has been found, and the prognosis is guarded, (McInnes & Schett, 2011). Unfortunately, rheumatoid arthritis is a debilitating disease that affects the body in the following ways: swelling and damage of the joints (synovitis); bone destruction; formation of autoantibodies, like rheumatoid factor (RF) and anti-citrullinated peptide (ACPA); persistent functional decline; vasculitis; fatigue; increased disability; dysphasia; stiffness and pain, mostly in the hands and wrist; functional limitations and physical disabilities; systemic manifestations that may include renal, eye , and vascular issues; cardiovascular disease and myocardial infarctions; ultimately leading to an increased

Rheumatoid Arthritis (RA) is the commonest form of inflammatory arthritis (Taylor 2007). It affects approximately 1% of the world population (Gibofsky 2012). Several western incidence and prevalence studies (Symmons et al. 2002; Helmick et al. 2008; Neovius et al. 2011; Widdifield et al. 2014; Fina-Aviles et al. 2016; Śliwczyński et al. 2016) of RA have been published, proposing a variation of the disease occurrence among different populations. However, the prevalence and incidence of RA are lessening in the western populations but prevalence remains alike (e.g. Sweden (0.77%) and the UK (0.81%) (Symmons et al. 2002; Neovius et al. 2011). RA is less common in low-income and middle-income countries (0.5% prevalence) compared to western

Rheumatoid Arthritis is a disease that many people suffer from. This is disease is very painful and cause your joints to swell and become stiff and restricts the motion of that that joint. This is an autoimmune disease that your immune system cells function improperly that causes them to attack the ligaments and joints. Also, it is genetic and environmental can play a role in this disease developing in the joints. This diseases symptoms are stiffness of the joints of over an hour, swollen joints, appetite or weight loss, and feeling fever in your joints. Allow it is hard for the doctors to diagnosis this diseases because it has many of the same side effects as other diseases. They run many tests and x rays trying to detect what is wrong. Rheumatoid

Rheumatoid arthritis (RA) is an autoimmune disease in which immune system of body mistakenly attacks the joints. This creates inflammation and severe pain around the joints due to thickening or degeneration of synovial fluid. Frequent high dosing of drug may precipitate side effect. Purpose of this work was site specific and simultaneously delivery of methotrexate and aceclofenac by chondroitin sulphate conjugated lipid nanocarrier i.e. solid lipid nanoparticles (SLNs) for the effective management of RA. The SLNs were prepared by solvent injection method and further they were surface engineered with Chondroitin sulphate. They were further characterized for size and its size distribution, shape and surface morphology, zeta potential,

Since this disease has chronic, systemic, autoimmune, and inflammatory characteristics, the initial diagnosis is rarely rheumatoid arthritis. The common use of the term arthritis “can oversimplify the nature of the varied disease processes and the difficulty in differentiating one from another” (Grossman, 2014, p. 1499). The diagnosis of rheumatoid arthritis is “made clinically based primarily on physical examination findings” (Gibofsky, 2012, p. 295), which can be a cause of misdiagnosis, since many diseases have overlapping presentations.

Rheumatoid arthritis (RA) is a chronic, complex and systemic inflammatory disorder that affects up to 1% of the population (1-2). It’s an autoimmune disease of unknown etiology. RA is associated with progressive joint destruction, systemic complications and early morbidity. The disease is characteristic of inflammation of the synovium, autoantibody production, cartilage and bone destruction and other systemic consequences, many of which include cardiovascular events. Although structural changes can be visualized by conventional imaging techniques, joint damage is rarely apparent in early stages of disease, but rather accumulates over time (3). Various immune modulators and signalling pathways are involved in the pathophysiology of RA. The influx

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