1. One of the big differences between "P-chem" standard state and "Biochem" standard state is the pH. The other (somewhat smaller) differences are temperature and pressure. PH Temperature Pressure P-chem 0 ([H+] = 1) 25°C 1 bar Biochem 7 37°C 1 atm Calculate the difference in the equilibrium constant and Gibb's energy for the hydrolysis of 1,3-biphosphoglycerate (1,3-BPG) assuming (a) "P-chem" standard state and (b) "Biochem" standard state. The typical cellular concentrations of the phosphate components of the reaction are given below. 1,3− BPG(aq) + H₂O(1)—3— PG(aq) + HPO²¯ (aq) + H+ (aq) 0.001mM 0.12 mM 1mM
1. One of the big differences between "P-chem" standard state and "Biochem" standard state is the pH. The other (somewhat smaller) differences are temperature and pressure. PH Temperature Pressure P-chem 0 ([H+] = 1) 25°C 1 bar Biochem 7 37°C 1 atm Calculate the difference in the equilibrium constant and Gibb's energy for the hydrolysis of 1,3-biphosphoglycerate (1,3-BPG) assuming (a) "P-chem" standard state and (b) "Biochem" standard state. The typical cellular concentrations of the phosphate components of the reaction are given below. 1,3− BPG(aq) + H₂O(1)—3— PG(aq) + HPO²¯ (aq) + H+ (aq) 0.001mM 0.12 mM 1mM
Principles of Modern Chemistry
8th Edition
ISBN:9781305079113
Author:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Chapter16: Solubility And Precipitation Equilibria
Section: Chapter Questions
Problem 70AP
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c) What volume of 1M HCl needs to be added to 1L of 0.10 M Tris to obtain a final pH of
7.4? Ignore dilution effects.
3. Blood pH must stay within ±0.4 from normal (pH 7.4). To do this a buffer system
involving carbon dioxide (product of respiration) is used. The following two equilibria are
involved:
and
a) What is the approximate range of molar concentrations of hydrogen ions for which
life can be sustained?
b) At pH 7.4 what are the concentrations of the two forms of carbonic acid if the total
concentration is 1 mM? The Ka for the H2CO3/HCO3- buffer pair is 4.3x10-7.
c) How can the body use this as a buffer system? (hint: think about La Chatelier’s
principle)
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