1. State all the products formed from Hofmann elimination of the following amine. Choose the major product. Show the mechanism to obtain the major product. а. b. с. NH, CH,CHCH3 NH2 NH2
Q: Heroin, a tertiary amine, is a weak base because it contains a nitrogen atom with a lone pair of…
A: Mass of the sample mixture taken for titration = 75.000 mg Molar mass of Heroin = 369.4176 g/mol
Q: What are the optimal pH values for imine formation? pH 9
A:
Q: 2) Propose two ways to synthesize the amine shown starting with an alkyl halide. (3
A: The reactions involving organic compound are known as organic reactions. Amines are organic…
Q: Which amines cannot be prepared by the Gabriel synthesis? Explain your choices.
A: EXPLANATION: The Gabriel Synthesis of primary amines: The Gabriel Synthesis consists of two steps…
Q: 13. Which sets of reagents could be used to efficiently make the following amine (i) 1-butylbromide…
A: Here we have to synthesize the following given compound N,N-dimethylbutanamine from the following…
Q: Predict the product of the hydrolysis reaction below. Show any amine functional groups as neutral.…
A: The detailed solution of your question given below--
Q: 4. If 0.082 mol of (±)-a-phenylethylamine are reacted with 0.083 mol of (+)-tartaric acid, then: a.…
A: A) (+) tartaric acid reacts with the (\pm)-\alpha-phenylethylamine to produce salt (-)-amine…
Q: Which amines cannot be prepared by a Gabriel synthesis? Explain your choices. NH2 NH2 NH2 а. b. C.…
A: Gabriel's phthalimide synthesis is used for the conversion of primary alkyl halide into primary…
Q: N-Substituted morpholines are building blocks in many drugs. Show how to synthesize…
A: The actual synthesis of N-methylmpholine from the given retrosynthetic analysis is to be drawn.…
Q: Complete the following acid-base reactions and predict the direction of equilibrium (to the right or…
A: of an acid is a measure of its strength. It is given by the expression where is the dissociation…
Q: Which of the following is FALSE about the reaction below? +0₂N NH₂ Select one: Oa. It is initiated…
A:
Q: um what is the Mechanis. 2% NaOH Me Me Me ELOH Me 94:6 P.M. McCurmy Ir Chamistry 1974, 39, 2316
A:
Q: Account for the following :(i) Primary amines (R-NH2) have higher boiling point than tertiary amines…
A: (i) Primary amines have hydrogens which can participate in intermolecular hydrogen bonding where…
Q: 1. Show the products of the reductive amination reactions below: a) Acetone + NH3, followed by…
A:
Q: Write the reaction (two-step, in skeletal) of each test amine when tested in the Hinsberg Test.
A: Hinsberg test is used to identify primary secondary and Tertiary amine.
Q: 38. The amine salt produced from the reaction of ethyl amine with HCl is: + A. CH3-CH₂-NH₂ Cl B.…
A: Organic reactions are those in which organic reactant react to form organic products.
Q: Complete the following acid-base reactions and predict the direction of equilibrium (to the right or…
A:
Q: Self Study/Amines-Reactions Name: 1) Show how m-toluidine (shown on the right) can be converterd to…
A: This is multiple subparts question, I will solved first three subparts for you with details…
Q: Afatoxin B1 is one of the most potent carcinogens known. Upon hydrolysis the highlighted group will…
A: In this question, we will Identify the functional group after the Hydrolysis of cyclic compound with…
Q: 8. Rank the following amines by basicity, from most basic to least basic. NH2 NH2 A B H,N Br
A: The basicity of an amine is increased by electron-donating groups and decreased by…
Q: 8. In the reaction below, why does the amine nitrogen (#1 in red) undergo protonation with H2SO4…
A:
Q: KMnO4, warm, conc'd reacts with hept-1-ene to yield __________. CO2, hex-1-ene CO2,…
A:
Q: NH₂ The following reaction will give 3 different organic products. Sketch the three products. CH3Br…
A: The Gabriel synthesis is a chemical reaction that transforms primary alkyl halides into primary…
Q: 1. Show the process of the conversion of amide to anhydride Components to use are the following:…
A: The process of conversion of amide to anhydride using the given components is shown below
Q: D Question 11 Identify all amines below that cannot be made via an azide synthesis (reaction with…
A:
Q: Q.1(a) Outline the retrosynthetic analysis and the designed synthesis of the following target…
A:
Q: The synthesis of an azo dye is shown below. Please answer the following questions. NH2 N2 1) NażCO3…
A: In this question, we will see which nitrogen is most basic Nitrogen in Compound - 3 You can see…
Q: Reduction of an alkyl azide results in the formation of —-. A. an imine B. an oxime C. a tertiary…
A: Alkyl azide have general formula R-N3
Q: - How would you prepare the following amines, using both Hofmann and Curtius rearrangements on a…
A: The Hofmann and Curtius rearrangement involves the conversion of carboxylic acid to an amine. The…
Q: 2-cyanophenol (pka 7.0) is even more acidic than the 4-cyanophenol isomer. Propose an explanation of…
A:
Q: Consider the following compounds that vary from nearly nonacidic to strongly acidic. Draw the…
A:
Q: acetaldehyde lactic acid - acetic acid Il only I only I and II I and III I, II, and III
A: Option A is correct choice || Only
Q: carcinogenic properties. Four students attempted to synthesize the dye using different starting…
A: Synthesis of Dye:
Q: Complete the following acid-base reactions and predict the direction of equilibrium (to the right or…
A: Given reaction,
Q: Q6:- Arrange the compounds of each set in order of basicity ? Explain your choice. ethylamine,…
A: Since you have asked multiple question, we will solve the first question for you.If you want any…
Q: Basicity of Amines Table 9.6 Observations on the basicity of each test sample. Sample Observations…
A:
Q: 2. (a) This problem deals with the acidity of amines, not their basicity (or the acidity of their…
A: "Since you have posted a question with multiple sub-parts, we will solve the first three subparts…
Q: Question 8 In the first asymmetric synthesis of (-)-(S,S)-homaline, a symmetric alkaloid isolated in…
A: Converting compound 1 to 2. The functional group changes are: Change of secondary amine to tertiary…
Q: Protonation of 1,1,3,3-tetramethyl-2-X-guanidine has been shown to occur on the imino nitrogen when…
A: In Hammett plots, ρ is given as the slope of the curve of log k versus the substituent constants, σ.
Q: Complete the following acid-base reactions and predict the direction of equilibrium (to the right or…
A:
Q: Draw the azo dye formed from the amine and coupling components (one mole each) shown below. NH₂ SO₂H
A: #1: During the azo dye formation, first the -NH2 group of aniline is converted to benzene diazonium…
Q: е. MgBr Et,O `OH
A: If there is an acidic proton(H+) present in the reactant then Grignard reagent work as base not as…
Q: The use of HNO2 in the diazotization reaction of amines is: Select one: O a. Transform the amine to…
A: Diazotization: Action of nitrous acid on aniline at 273-278 K gives benzene diazonium chloride. And…
Q: 1. Show the process of the conversion of amide to anhydride Components to use are the following: •…
A: This will be solved by three step which was mentioned by the question. 1. When amide under goes…
Q: Which amines cannot be prepared by the Gabriel synthesis? Explain your choices
A: The Gabriel Synthesis of primary amines: The Gabriel Synthesis consists of two steps and uses a…
Q: 1. State all the products formed from Hofmann elimination of the following amine. Choose the major…
A: Hofmann's elimination : Hofmann's elimination is the process of creating tertiary amines and alkenes…
Q: تحصال a danger o déce CO₂Me O₂Me 1,3-dix 2. OH FG Ph NH₂ + 22 21 20 19 synthesis is straightforward…
A:
Q: Hello, can you list the basicities from large to small with reasons? a) Aniline b) Pyridine c)…
A: The structures for the given bases are as follows: The base is an electron pair donor. Greater the…
Q: Place the binders below in descending order of acidity (pi) and justify your choice: CH3CN;…
A: Concept - i) Acidity is directly proportional to Electronegativity and -I inductive effect. ii)…
Q: Which amines cannot be prepared by the Gabriel synthesis? Explain your choices
A: Gabriel synthesis: Gabriel synthesis is a chemical reaction that transforms an alkyl halide into a…
Step by step
Solved in 2 steps with 2 images
- Predict the major product of the reaction. starting material O А. B. D. Е. OH OH 1. BH3 2. NaOH, H. H2O ОН OH H OH enol intermediate productGalantamine, a natural product produced by the amaryllis family of flowering plants, has been used in the early treatment of Alzheimer's disease. In a synthesis of galantamine and related compounds (J. Org. Chem. 2015, 80, 1952-1956), compound 1 was converted into compound 2. Propose an efficient synthesis for the conversion of 1 to 2 A. NaOH MeO D. DMP or PCC G. HBr MeO B. H₂SO4, H₂O, HgSO4 E. Na2Cr₂O7, H₂SO4, H₂O H. 1) O3; 2) DMS H 2 The conversion of 1 to 2 can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order for each transformation, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. C. 1) BH3-THF; 2) H₂O2, NaOH F.HBr, ROOR I. TsCl, py Meo I₁, N Me Galanthamine OHGive the major organic product(s) for each step of the following reactions: H2 NaCN В HCI/H20 SOCI2 ►E HBr A a) Lindlar 1. NaOH, д -D 2. H* CH3CH2OH 1, 2 eq CH3CH2M9B A- В H30* 2. Hзо* LDA - C b) 1. ВНз/THF HBr 1. C 2. H30* A Mg В Et,0 D 2. H2O2, OH", H20 c)
- An acetal produces the following three compounds upon hydrolysis. Of acetals A-E which could it be? H3CO OCH3 П A B U D Acetal A H2O H₂SO4(cat.) замен поста "OCH3 В + HO. H₂CO ОН D + OCH3 CH3OH E OCH3 "OCH33. Provide mechanisms for the following reactions. OH a. 18OH b. C. HO H₂180 cat. H H₂O -C=N: cat. H* 180 →EtOH + CH3CH₂CH₂CO₂H cat. CH3SO3H NHBelow is a structure of Levonorgestrel (Plan B®), used in prevention of pregancy. но HH H. Levonorgestrel Plan B® Below is one of the reactions used in the synthesis. What type of reaction is it? он :CEC-H Lc=c-H THF as solvent Levonorgestrel H,CO H,CO O A grignard reaction. Nucleophilic acyl substitution. O Nucleophilic addition. O An SN2 reaction. O O
- H₂C ཏཱཏི 1 ནི OH 1. Br2, PBг3 2. H₂O H3C OH Br The a-bromination of carbonyl compounds by Br2 in acetic acid is limited to aldehydes and ketones because acids, esters, and amides don't enolize to a sufficient extent. Carboxylic acids, however, can be a-brominated by first converting the carboxylic acid to an acid bromide by treatment with PBr3. Following enolization of the acid bromide, Br2 reacts in an a-substitution reaction. Hydrolysis of the acid bromide completes the reaction. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions :0: H3C Br Br + :::OH2 Br H₂O H3C Br заWhat is the major organic product obtained from the following sequence of reactions? A. HNO3, H₂SO4 CEN NO₂ B. H₂, Pd/C CN NO₂ Na₂Cr₂O7 H₂SO4 CN D COOH CN 1. NaNO₂, HCI 2. CUCN E CN NO₂3B Complete the reactions below. OH NaBr/H₂SO4 D Mg Et₂O E (2 ισοδ) 1. HCOOEt Et₂O 2. H₂O/H* F
- Propose a synthesis of the topical anesthetic cyclomethycaine from 4-hydroxybenzoic acid, 2-methylpiperidine, and any other necessary reagents. HN' + HO. НО Cyclomethycaine 4-Hydroxybenzoic acid 2-MethylpiperidineWhat is the best set of reagents to achieve deoxygenation of 2-pentanone to pentane? A. NaClO2/NaH2PO4 B. LiAlH4, Et2O C. DIBAL-H, THF D. NH2NH2/t-BuOK, DMSOIdentify the major product obtained when this compound is treated with fuming sulfuric acid. SO3 .SOH FoS. I II III IV V IV OI O II