1.Growth factor binding and dimerization Tyrosine kinase domain Growth factor 2. Autophosphorylation Growth factor Grb2 4. Complex assembly Ras GDP SOS (GEF) 3.Binding of adaptor proteins such as Grb2 GDP 5.Guanine nucleotide exchange and activation of Ras GTP Ras GTP Raf 6.Ras binds raf and initiates MAP kinase pathway Is the phosphorylated tyrosine kinase active or inactive? This pathway controls proliferation and cell survival. What is the general type of ligand for tyrosine kinase receptors? What is autophosphorylation?
1.Growth factor binding and dimerization Tyrosine kinase domain Growth factor 2. Autophosphorylation Growth factor Grb2 4. Complex assembly Ras GDP SOS (GEF) 3.Binding of adaptor proteins such as Grb2 GDP 5.Guanine nucleotide exchange and activation of Ras GTP Ras GTP Raf 6.Ras binds raf and initiates MAP kinase pathway Is the phosphorylated tyrosine kinase active or inactive? This pathway controls proliferation and cell survival. What is the general type of ligand for tyrosine kinase receptors? What is autophosphorylation?
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
Section: Chapter Questions
Problem 12RQ: Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway...
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