2', 3'-Dideoxyinosine has been approved as an anti-HIV drug. Propose a mechanism by which it might block the growth of the HIV virus. Match the words in the left column to the appropriate blanks in the sentences on the right. dideoxynucleoside 3' triphosphate dideoxynucleoside 5' phosphate + endonuclease dATP 5' phosphate terminus dGTP dideoxynucleoside 3' phosphate Dideoxyinosine (ddl) is taken up into the cell and converted to the corresponding Incorporation of this nucleotide in place of because of the absence of a Reset Help it incorporates replication of the viral genome to be selectively inhibited. would block further chain elongation The HIV reverse transcriptase lacks a more readily than do the cellular replicative polymerases, causing SO
2', 3'-Dideoxyinosine has been approved as an anti-HIV drug. Propose a mechanism by which it might block the growth of the HIV virus. Match the words in the left column to the appropriate blanks in the sentences on the right. dideoxynucleoside 3' triphosphate dideoxynucleoside 5' phosphate + endonuclease dATP 5' phosphate terminus dGTP dideoxynucleoside 3' phosphate Dideoxyinosine (ddl) is taken up into the cell and converted to the corresponding Incorporation of this nucleotide in place of because of the absence of a Reset Help it incorporates replication of the viral genome to be selectively inhibited. would block further chain elongation The HIV reverse transcriptase lacks a more readily than do the cellular replicative polymerases, causing SO
Chapter16: Adult And Pediatric Dosages Based On Body Surface Area
Section: Chapter Questions
Problem 7.2P
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