2. Achondroplasia is a form of dwarfism caused by a dominant allele. The homozygous dominant genotype causes prenatal death, so individuals who have this condition are all heterozygotes. In the questions below, show how you came to your answer. a) If a person with achondroplasia mates with a person of average height who does not have achondroplasia, what percentage of their children would be expected to be of average height? b) If two persons with achondroplasia have children, what percentage of their children would be expected to have achondroplasia?
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- Why is the chances of having a child with down's syndrome increases if the age of mother exceed forty year?A certain couple has six children – four boys (ages 2yr, 5yrs, 9yrs and 11yrs old) and two girls (ages 5yrs and 7yrs old). The oldest boy shows the symptoms of Duchenne Muscular Dystrophy (DMD). What are the chances of their other children developing the disease?A woman with achondroplasia (a dominant form of dwarfism) anda phenotypically unaffected man have seven children, all of whomhave achondroplasia. What is the probability of producing such afamily if this woman is a heterozygote? What is the probabilitythat the woman is a heterozygote if her eighth child does not havethis disorder?
- In terms of ontigeny, differentiate the following; A. Epiphysis from hypophysis B. Retina from organ of CortiState the probability of a male child being affected and ofa female child being affected if the mother carries a genefor a sex-linked recessive disorder. What if it is the fatherwho carries the gene?If diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this an indication that there is a genetic contribution to these traits? What would you do to confirm that genetics is involved in this condition?
- 1) Suppose thatt everyone in your family (bloodline) has attached earlobes. Do you know with certainty what your gentype is? a) Your spouse also has attached earlobes, but both your children have unattached earlobes. What is your genotype, and what is your spouse's genotype?A) Is it ever possible for two unaffected parents (they are average height) to have a child with achondroplasia? Explain your answer. B) Is it possible for two parents with achondroplasia to have a average height son (if so how often would you expect to see if occur-give ratios)? Explain your answer and explain how often this could happenNeither Tim nor Rhoda has Duchenne muscular dystrophy, but their firstborn son does. What is the probabilitythat a second child will have the disease? What is theprobability if the second child is a boy? A girl?
- Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28 th year. Her sister, who married an unaffected man, has two affected sons and a normal daughter.You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD). a. Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation. b. What is most likely the pattern of inheritance for this condition? c. Justify your answer in letter (b).d. What is the risk (probability) that the fetus is affected?…Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28 th year. Her sister, who married an unaffected man, has two affected sons and a normal daughter.You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD).What is the probability that 3 of the children will exhibit Cystic fibrosis and 1 child not affected?