3. Above is a relative of S-adenosylmethionine (SAM) called S-adenosvlmethionineamine (while there is no common abbreviation for this molecule, here we can call it SAMN). Note that R'-S-R is a very good leaving group. You do not need to know anything else about sulfur to answer this question. It is recommended to work this problem after Problem 2, keeping in mind the three circled carbon atoms from Problem 2. To save excessive writing, you may abbreviate adenosine as "Ado" as shown in the pathway diagram below. a) b) SAMN can serve as more than a methylating agent. Do you think that its intrinsic chemical activity as a methylating agent is substantially more, similar to, or less than SAM? SAMN is used in biochemistry in the below pathway, which converts the stinky diamine putrescine into the "polyamine" spermine which is used biologically for offsetting the negative charges in DNA. Draw spermine in its most common protonation state at pH 7. c) Draw the reaction of putrescine with SAMN (shown as with the adenosine abbreviated as "Ado" in the below diagram) to form spermidine using the arrow formalism. putrescine H₂N- H₂N spermidine synthase H₂N spermine synthase NH₂ H₂N. S-Ado NH₂ spermidine NH₂ spermine
Electronic Effects
The effect of electrons that are located in the chemical bonds within the atoms of the molecule is termed an electronic effect. The electronic effect is also explained as the effect through which the reactivity of the compound in one portion is controlled by the electron repulsion or attraction producing in another portion of the molecule.
Drawing Resonance Forms
In organic chemistry, resonance may be a mental exercise that illustrates the delocalization of electrons inside molecules within the valence bond theory of octet bonding. It entails creating several Lewis structures that, when combined, reflect the molecule's entire electronic structure. One Lewis diagram cannot explain the bonding (lone pair, double bond, octet) elaborately. A hybrid describes a combination of possible resonance structures that represents the entire delocalization of electrons within the molecule.
Using Molecular Structure To Predict Equilibrium
Equilibrium does not always imply an equal presence of reactants and products. This signifies that the reaction reaches a point when reactant and product quantities remain constant as the rate of forward and backward reaction is the same. Molecular structures of various compounds can help in predicting equilibrium.
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