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- Calculate the creatinine clearance for Lola, a 69 year old woman who weighs 66kg and has a serum creatinine of 125micromoles/L. Round your answer to 2 decimal places Cockroft Gault equation: [ X (140-age) x (weight in kg)] / serum creatinine (in micromole/L) Where X = 1.04 for females and X = 1.23 for malesA 79 kg man is admitted to hospital following a suspected overdose of drug G. When he is admitted to hospital on the 3rd October at 23:00 his plasma concentration of drug G is 12 mg/mL. Given that the half-life (t½) of drug G is 10.5 hours. What would you expect his plasma concentration of drug G to be at 17:00 on the 5th October? Give the answer in microg/ml. (You may assume that the distribution is complete and the elimination is described by a 1storder process.)A 72-year-old adult patient who weighs 78 kg is prescribed by the doctor “Potassium Chloride 40meq in 1L to run for 8 hours” via the peripheral line for a potassium level of 3.3 mEq/L that was drawn this morning. Note: 10 mEq of potassium chloride increases serum potassium levels by approximately 0.1 mEq/.L The concentration of potassium for intravenous administration via a peripheral line should not exceed 40mmol / 500 mL 10 mEq/hr maximum infusion rate; not to exceed 200 mEq dose/24hr Administration rates above 20mmol/hour require cardiac monitoring. How much will the order medication “Potassium Chloride 40meq in 1L to run for 8 hours” raise the patient's potassium level in a day? Is it still within the normal potassium serum levels, which is 3.5–5.0 mEq/L? Does the order comply with the maximum concentration of potassium to be administered peripherally? Does the order’s infusion rate do not exceed the standard maximum infusion rate? Does the order require cardiac monitoring?
- 4) 0.1 ml of a blood sample is added to 9.9 ml of sterile saline.1 ml of this dilution is then added to 9 ml of sterile saline. 1 ml of this dilution is plated , and 37 colonies form. What is the CFU/ml of the blood sample? 5) 5 ml of urine is added to 70 ml of water . 1ml of the diluted urine is plated, and 163 colonies form. What is the CFU/ml of the urine ?A creatinine clearance is done on a patient with the following results: serum creatinine, 0.6 mg/dL; urine creatinine, 102 mg/dL; urine volume, 1650 mL/24 hours; body surface area, 1.93 m2. Based on the information from calculations above, which of the following is the best interpretation of this patient's creatinine clearance results? 1) Within the normal range 2) Above normal, probably because the 24-hr urine collection was not completed correctly 3) Above normal 4) Below normal no references, just homeworkAfter oral administration of single 250 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 50 mg.hr/L. After intravenous bolus administration of 100 mg, the AUC was 100 hr/L. explain the way plz What is the the absolute bioavailability of the drug from the tablet applied orally? (10. SLAYT) A) 60 % B) 20 % C) 50 % D) 75 % E) 40 %
- 23. If a healthy person is given an infusion of hypertonic saline (3% NaCl), which of the following findings in plasma is most likely? OA) Plasma [ADH(vasopressin)] pg/mL 10 B) 5-E 0- DK 300 C 280 290 Plasma osmolality (mOsmol/L) O Control before infusion C) B 310 D) OE)After oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT) A) 60% B) 20% C) 40% D) 50% E) 75% What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT) 1 mg/ml 200 mg/ml 20 mg/ml 5 mg/ ml 10 mg/ ml42. An investigator is conducting a clinical study of the effects of ADH (vasopressin) on whole body fluid balance. The plan is to produce increased circulating concentrations of ADH. Following a 5% change from baseline, which of the following will be the most effective physiologic stimulus for increasing ADH secretion in this study? A) Decrease in blood pressure B) Decrease in blood volume C) Increase in serum osmolality D) Increase in fluid intake E) Increase in hematocrit
- 1.8 Which of the following is likely to cause the kidney to change the reabsorption of water and/or NaCl? Select one: a. Drinking 1 L of water in a short period of time. (Assume that you weren't dehydrated.) b. Eating a big bag of salty potato chips. c. Forgetting to drink water all day. d. Exercising vigorously in a very hot environment. e. All of the above18. Esmolol 1.2 g in 500 mL D5W has been ordered at a rate of 100 mcg/kg/min for a client weighting 103.2 kg. Determine the following: a) dosage in mcg/min: b) rate in mL/hr c) Is the dosage administered to the client safe?Mrs B, aged 43 years, weight 56 kg, requires a loading dose of drug B. The target plasma concentration is 18.9 mg/ L, volume of distribution is 0.5 L/ kg, the salt factor is 0.9 and bioavailability fraction is 1. What is the intravenous loading dose (LD) of Drug B in milligrams (mg)? units - mg LD = Cp desired x Vd S x F Where Cp desired is the target plasma concentration; Vd is the volume of distribution; S is the salt factor and F is the bioavailability fraction