A patient received a single 245.97 mg IV bolus dose of an antibiotic and the plasma drug concentration was determined as 13.62 mg/L and 5.94 mg/L at 2.04 hours and 11.52 hours following the drug administration, respectively. On a separate occasion, a single 427.73 mg oral dose of the same antibiotic was administered to the same patient and the plasma drug concentration was determined as 0, 5.01, 5.77, 3.43, 1.1 mg/L at 0, 3.15, 7.69, 14.39, and 27.5 hours following the drug administration. Please calculate the bioavailability of this drug without utilizing any data fitting program.

A patient received a single 245.97 mg IV bolus dose of an antibiotic and the plasma drug concentration was determined as 13.62 mg/L and 5.94 mg/L at 2.04 hours and 11.52 hours following the drug administration, respectively. On a separate occasion, a single 427.73 mg oral dose of the same antibiotic was administered to the same patient and the plasma drug concentration was determined as 0, 5.01, 5.77, 3.43, 1.1 mg/L at 0, 3.15, 7.69, 14.39, and 27.5 hours following the drug administration. Please calculate the bioavailability of this drug without utilizing any data fitting program.

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter10: Reconstitution Of Powdered Drugs

Section: Chapter Questions

Problem 7.2P

See similar textbooks

Similar questions

The drug dosage for the patient is calculated using a BSA of 1.9m2. If the order is 15mg per m2, how many milligrams is the desired dose?
rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1
Using conversion factors, solve each of the following clinicalproblems:a. A nurse practitioner prepares an injection of promethazine,an antihistamine used to treat allergic rhinitis. If thestock bottle is labeled 25 mg /mL and the order is a doseof 12.5 mg, how many milliliters will the nurse draw up inthe syringe?b. You are to give ampicillin 25 mg/kg to a child with a massof 62 lb. If stock on hand is 250 mg /capsule, how manycapsules should be given?
a) What are the methods used for cholesterol determination? Explain the basis of the method you used in your experiment by writing.b) In the experiment conducted for the determination of cholesterol, the function of the calibration curve obtained using standard cholesterol solutions of 25-400mg/dl was determined as y= 0.0009x.Since the absorbance of the serum sample was determined as 0.28, how many mg/L is the amount of cholesterol in the sample
If a pharmacist added each of the following to 22-g packages of 2% mupirocin ointment, what would be the percentage strengths of the resulting ointments: (a) 0.25 g mupirocin powder and (b) 0.25 g of nonmedicated ointment base? (answer to two decimal places). answers: (a) 3.10% w/w (b) 1.98% w/w
a) The total amount excreted into urine as unchanged drug after an oral tablet (A) of 50 mg was 36.4 mg. After an oral capsule dose (B) of 25 mg the Uo was 20.3 mg. Calculate the relative bioavailability of the tablet A with respect to capsule B. If the absolute bioavailability of the oral capsule is determined to be 0.86 calculate the absolute bioavailability of the tablet dosage form. You are required to list the given data, formula and steps for calculations
Your 67 YO 195lb, 5ft 10in male patient diagnosed with testicular cancer has been prescribed ifosfamide 1200mg/M2/day IV for 5 days. You calculate the BSA using the mosteller method as being 2.09m2. Ifosfamide is available in 60mL vials contianing 3g of drug. a) How many mL will you administer each day?
Treatment with the drug carvedilol for heart failure is initiated with a dose of3.125 mg twice daily and then increased every two weeks with twice-daily doses of6.25 mg, 12.5 mg, and 25 mg. How many of each of these tablet strengths shouldbe dispensed for this protocol?
A patient is prescribed venlafaxine 37.5 mg daily for 7 days, increasing by 37.5 mg every week until a maximum daily dose of 225 mg is reached. A total of 8 weeks treatment must be dispensed. You supply your total stock of 84 venlafaxine 37.5 mg tablets. How many tablets are still owed to the patient?
A patient is prescribed Cipro for an upper espiratory tract infection. The oral suspension is labelled 200 mg/5 mL and the patient needs to take 800 mg every 12 hours for 7 to 15 days. How many ug are in each dose? How many mL must the patient take in each dose? How many g of Cipro is the patient taking every 24 hours? What is the molarity of the Cipro oral suspension? MW Cipro=331.35 g/mole
For the TylenolTM dose, calculate how much (in mg) did Erthy consume for all six doses. To do that, you will need the following information: Mrs. AB used a 100 mL bottle of TyelnolTM (concentration is 160 mg per 5 mL) and followed the package instructions (1.5 tsp per dose for a child weighing 16 – 21.9 kg).
A 10-day-old neonate born at 36 weeks gestation and weighing 3265 g is prescribed gentamicin, 4mg/kg in 30 mL/kg of D10W for IV infusion. If an injection contains gentamicin 40 mg/mL, how many milliliters each of gentamicin injection and D10W should be added to an empty IV bag and administered to the patient?