A typical amino acid with one amino group and one carboxylic acid group, such as serine can exist in water in several iconic forms. Suggest the forms of the amino acid at low pH and at a high pH. Amino acids generally have two pKa values, one in the range of 2 to 3 and the other in the range of 9 to 10. Serene, for example, has pKa values of 2.91 and 9.21. Using species such as acetic acid and ammonia as models, suggest the origin of the two pKa values. Glutamic acid is an amino acid that has three pKa’s: 2.10, 4.07, and 9.47. Draw the structure of glutamic acid and assign each pKa to the appropriate part of the molecule. An unknown amino acid is titrated with strong base, producing the following titration curve. Which amino acid are likely candidates for the unknown?
A typical amino acid with one amino group and one carboxylic acid group, such as serine can exist in water in several iconic forms. Suggest the forms of the amino acid at low pH and at a high pH. Amino acids generally have two pKa values, one in the range of 2 to 3 and the other in the range of 9 to 10. Serene, for example, has pKa values of 2.91 and 9.21. Using species such as acetic acid and ammonia as models, suggest the origin of the two pKa values. Glutamic acid is an amino acid that has three pKa’s: 2.10, 4.07, and 9.47. Draw the structure of glutamic acid and assign each pKa to the appropriate part of the molecule. An unknown amino acid is titrated with strong base, producing the following titration curve. Which amino acid are likely candidates for the unknown?
Chapter8: Polyfunctional Acids And Bases
Section: Chapter Questions
Problem 14P
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- A typical amino acid with one amino group and one
carboxylic acid group, such as serine can exist in water in several iconic forms.
- Suggest the forms of the amino acid at low pH and at a high pH.
- Amino acids generally have two pKa values, one in the range of 2 to 3 and the other in the range of 9 to 10. Serene, for example, has pKa values of 2.91 and 9.21. Using species such as acetic acid and ammonia as models, suggest the origin of the two pKa values.
- Glutamic acid is an amino acid that has three pKa’s: 2.10, 4.07, and 9.47. Draw the structure of glutamic acid and assign each pKa to the appropriate part of the molecule.
- An unknown amino acid is titrated with strong base, producing the following titration curve. Which amino acid are likely candidates for the unknown?
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