Arrange the following compounds in the decreasing order of pka values. он он он CH;CH,CH,OH CH;-ÇH-CH,OH ČH3 NO2 1 3 4 5 A) 4,5,3,2,1 B 1,2,3,5,4 1,2,3,4,5 D 1,2,4,5,3

Q: Why is the pKa of the Ha protons in 1-acetylcyclohexene higher than thepKa of the Hb protons?

A: In this question, we will discuss about why pKa value for Ha proton will be greater than Hb proton.…

Q: 7) a) Assign R and S configuration to the chirality centers of molecules 28 and 29. II II CH3 H3C H…

A: From the rate equation, it is clear that all three reactions are SN^2 in nature. Hence, in all cases…

Q: Streptimidone is an antibiotic whose structure is shown below. Which of the following gives the…

A: Priority  is given According to elements  having higher atomic mass .

Q: THE T S PRODUCT WHAT RESULTENC FROM THE ELIMENATCA RxN CampovNO 1 TH F? GF OTASSIUM WITH T-BUTOXTDE…

A: The main requirement for E2 elimination is that both the leaving groups should be anti periplanar to…

Q: calkulate the molkcular HO OH Weight 2 R O=C Where ( R) is : CH,COOH 3-6 CH2-N CH2COOH 3 H = 1,C= 12…

A: The compound given is,

Q: There is restricted rotation around carboncarbon double bonds. Maleic acid and fumaric acid are two…

A: Comparing the mp we can tell that the mp of the maleic acid is less than fumaric acid because it is…

Q: Match each compound with its appropriate pKa value. Q.) Benzoic acid, cyclohexanol, phenol pKa 5…

A: Compound with their pKa values:

Q: 5. You run the following reaction in lab and take a 'H NMR spectrum of the product. Determine the…

A: The reaction involved the formation of a carbocation intermediate. So it can be called an SN1…

Q: 4. Give R and S configuration to the following compounds. OH CH CH3 CHa HO

A: Configurations: R S R R

Q: но 10. Bryostatin is a cyclic polyketide natural product synthesized biologically by the sessile…

A: Total number of stereo isomers can be found from the number of stereo genic centers. A stereo genic…

Q: 23. Draw the final product and identify R or S or racemic in all chiral centers in the product. Ph,…

A: Given that : We have to draw the final product and identify the R or S racemic in all the chiral…

Q: Hello, I need help with question 26 a-f. I need help with the while problem.

A: Hey, since there are multiple sub-part questions posted, we will answer first three sub-parts…

Q: Consider the structure of one enantiomer of warfarin (top right), an essential drug that exhibits…

A: Warfarin is an essential drug that exhibits anticoagulant activity by inhibiting vitamin-k epoxide…

Q: c) The pKa of H-CH3 is roughly 50. The pKa of H-CBR3 is 14, briefly explain the difference in pKa,…

A: Given that pka of CH4 is 50 and that of CHBr3 is 14. Greater the acidity, lesser is the pKa value.…

Q: SCH Aon go nue 2. Which of the following compounds ort ot contains a substituent that is ortho/para…

A:

Q: Which one of the following compounds contains alpha-hydrogens with a pk, value of about 13? CH3CCH3…

A: The alpha hydrogen of the carbonyl compounds is acidic in nature. If a hydrogen atom contains two…

Q: 27(a) Identify in the following pairs: 1. Strongest base A or B? A. (CH3)2 NH (pKa = 10.49) B.…

A:

Q: d) What is the IHD (index of hydrogen deficiency) of the following compound? (don't calculate the…

A: d)  The hydrogen deficiency index can be calculated by the number of the double bonds (pi-bonds) and…

Q: 4) Assign R or S configuration to the following molecules: CH2CH2CH2 CH3 CH, Br CH2CH3 NH2 H3C…

A: Since you have posted a  question with sub-parts , we are entitled to answer the first three…

Q: Draw both diastereomers of 2-bromo-3-chlorobutane by editing the two drawings of…

A:

Q: KSP ds-

A:

Q: 6. Stereochemistry! Determine the R and S configuration of the following Fischer and Chair drawings:…

A: The detailed answers have been provided.

Q: 4-Formylbenzoic acid could be reduced using different reducing agents and could produce A and B as…

A: Sjs

Q: C6H100, IR (cm-1): 2110, 3300 cm1 (sharp), 1H NMR (8): 3.31 (3H, s); 2.41 (1H, s), 1.43 (6H, s) H- I…

A:

Q: Estimate the pKa values of the following compounds:  a. CH3CH2CH2NH2 b. CH3CH2CH2OH  c.CH3CH2COOH…

A: The pKa values of the following compounds are to be estimated:   CH3CH2CH2NH2  CH3CH2CH2OH…

Q: 2 Rank the labeled protons in the following molecule in order of increasing pK. He H. он,

A: Stronger the acid , smaller the pKa value. pKa = -logKa

Q: Match each compound with its appropriate pKa value. Q.) 4-Nitrobenzoic acid, 4-nitrophenol,…

A: pKa value is the measure of acidity of the solution. More the pKa,lesser will be the acid…

Q: What is the percent composition of a mixture of (S)-(+)-2-butanol([a] = +13.520), and…

A: The specific rotation of (S)-(+)-2-butanol is = 13.52o The specific rotation of the mixture is =…

Q: Streptimidone is an antibiotic whose structure is shown below. Which of the following gives the…

A: We will give R/S notation according to CIP rule.

Q: Identify the indicated hydrogens in the molecules below as pro-R or pro-S. Ho Ha CO2H H3*N H…

A: • When a tetrahedral carbon can be converted into chiral center by   changing only one of the…

Q: Please solve problems 4& 5

A: The mixture of HCl and ZnCl2 is Lucas reagent. In presence of Lucas reagent, secondary and tertiary…

Q: A 50:50 mixture containing the compounds below is expected to be optically inactive. !!!!!IC/ OH CI…

A: Optical activity refers to a property of a compound or mixture to rotate plane polarized light to…

Q: For the compound shown, the most probable site(s) of electrophilic aromatic substitution is/are: OH…

A:

Q: Estimate the pKa values of the following compounds: a. CH3CH2CH2NH2 b. CH3CH2CH2OH c. CH3CH2COOH d.…

A: pKa is defined as -log10 Ka where Ka = [H+][A-] / [HA] It tells us that when the pH = pKa then log…

Q: Hc Ha oHe Hb -Hd i) rank the labelled þrotons in order of increasing pK . ") Explain your answer in…

A:

Q: Which molecule below has the lowest pKa? O A B D OH A OH B с OH F D ОН

A: (B) phenol is the strongest acid, therefore it has the lowest pKa.

Q: Structure: OMe Bicyclo[2.2.1]hept- 5-ene-2-carboxylic acid methyl ester Predict Diastereotopic…

A: The carbon has tetravalency, which means that it has the ability to form four bonds. Every carbon…

Q: 3. Rearrange the molecules from strongest IMFS to weakest. C,H0 C,H, CH C,H

A: Answer:- This question is answered by using the simple concept of intermolecular forces (IMF) of…

Q: 2.52 Rank the labeled protons in the following molecule in order of increasing pkg.

A:

Q: A. Shown below are the Fischer projections of four isomeric phosphorylated tetroaldoses. One of…

A: We have to check the configuration of each stereocentre by using CIP rules . Compoumd which are…

Q: cat. Pd NAOH H3C -B(OH)2 + Br -CH,OH THE b) In the 'HNMR spectrum for 4-bromobenzyl alcohol, assign…

A: The explanation is given below-

Q: 10. Bryostatin is a cyclic polyketide natural product synthesized biologically by the sessile marine…

A:

Q: Arrange the following compounds in the decreasing order of pKa values. OH OH OH CH;CH,CH,OH…

A:

Q: clearly indicate your assignments of all pro 1.37 17. Draw the structures of Compound 17a. and 17b.…

A:

Q: Why is the pKa of the Ha protons in 1-acetylcyclohexene higher than the pKa of the Hb protons?

A: pKa is the measure of negative log of dissociation constant (Ka) of an acid. Hence, lower the pKa…

Q: 4. Deduce the structure for Compound Y which has a molecular formula CH,CIO; given its "HNMR and…

A:

Q: Arrange the following compounds in the decreasing order of pKa values. OH OH CH;CH,CH,OH…

A: Acidity of a compound directly proportional to the stability of its conjugate base. Higher is the…

Organic Chemistry of Metabolic Pathways

Metabolic pathways allude to the arrangement of chemical catalyzed reactions that lead to the transformation of a substance into the final product. Metabolic pathways incorporate a progression of reaction where the substrate is changed continuously and the transitional metabolites are persistently recovered.

Glucogenesis

Glucogenesis is a metabolic pathway in which glucose is produced from carbon substrates that are not carbohydrates. This process is observed in plants, animals, fungi, bacteria and other micro organisms. The general  definition for glucogenesis or gluconeogenesis is as follows,