ase choose the FALSE statement: Group of answer choices In AAV and RTV, the mutant genes are not removed You cannot create new traits such as blue skin in offspring using pre-implantation screening AAV gene therapy only works in somatic cell transformation Similar to RTV, AAV gene therapy adds genes tha

ase choose the FALSE statement: Group of answer choices In AAV and RTV, the mutant genes are not removed You cannot create new traits such as blue skin in offspring using pre-implantation screening AAV gene therapy only works in somatic cell transformation Similar to RTV, AAV gene therapy adds genes tha

Comprehensive Medical Terminology

4th Edition

ISBN:9781133478850

Author:Jones

Publisher:Jones

Chapter21: Oncology (cancer Medicine)

Section: Chapter Questions

Problem H9CRE

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Answer the following miscellaneous questions from various topics you studied in biotechnology course: Mention the challenges and potential problems while targeting tumor cells by using monoclonal antibodies?
You are in charge of a new gene therapy clinic. Two cases have been referred to you for review and possible therapy. Case 1. A mutation in the promoter of a proto-oncogene causes the gene to make too much of its normal product, a receptor protein that promotes cell division. The uncontrolled cell division has caused cancer. Case 2. A mutation in an exon of a tumor-suppressor gene makes this gene nonfunctional. The product of this gene normally suppresses cell division. The mutant gene cannot suppress cell division, and this has led to cancer. What treatment options can you suggest for each case?
The following family has a history of inherited breast cancer. Betty (grandmother) does not carry the gene. Don, her husband, does. Dons mother and sister had breast cancer. One of Betty and Dons daughters (Sarah) has breast cancer; the other (Karen) does not. Sarahs daughters are in their 30s. Dawn, 33, has breast cancer; Debbie, 31, does not. Debbie is wondering if she will get the disease because she looks like her mother. Dawn is wondering if her 2-year-old daughter (Nicole) will get the disease. a. Draw a pedigree indicating affected individuals and identify all individuals. b. What is the most likely mode of inheritance of this trait? c. What are Dons genotype and phenotype? d. What is the genotype of the unaffected women (Betty and Karen)? e. A genetic marker has been found that maps very close to the gene. Given the following marker data for chromosomes 4 and 17, which chromosome does this gene map to? f. Using the same genetic marker, Debbie and Nicole were tested. The results are shown in the following figure. Based on their genotypes, is either of them at increased risk for breast cancer?
Figure 17.15 In 2011, the United States Preventative Services Task Force recommended against using the PSA test to screen healthy men for prostate cancer. Their recommendation is based on evidence that screening does not reduce the risk of death from prostate cancer. Prostate cancer often develops very slowly and does not cause problems, while the cancer treatment can have severe side effects. The PCA3 test is considered to be more accurate, but screening may still result in men who would not have been harmed by the cancer itself suffering side effects from treatment. What do you think? Should all healthy men be screened for prostate cancer using the PCA3 or PSA test? Should people in general be screened to find out if they have a genetic risk for cancer or other diseases?
Following is the data and notice that it is a terrible idea to culture hMSCs longer than 10 days. You’re strongly Days # cells0 50001 75002 125003 125004 218005 287006 530007 1143008 1653009 19200010 19200011 11680012 8950013 8830014 78300 Part1 You are working for a start-up that is pursuing a clinical trial. The trial involves grafting hMSCs intopatients suffering from interveterbral disc disease using a degradable polymer scaffold. You are going to 3Dprint a porous cylindrical scaffold that is 2 cm in radius and 1 cm in height (matching the dimensions of adegenerated disc). Assume a porosity of 50%. You will fill available volume of the scaffold with hMSCs at adensity of 1 million cells per cm3. Based on the data above, what starting number of cells will you use andhow long will it take you to get enough cells for the trial? Part2The trial is a failure (patients did not report any reduction in back pain). Your team wants to try againusing 85% hMSCs and 15% nucleus pulposus cells .…
Options : Sex XY mutations reversal SRY feminization
Which of the following is NOT an advantage of autologous embryonic stem cell development and differentiation in-vitro? O They can be used to treat degenerative or damaged tissues without being rejected by the individual's immune system O They have very high pluripotency O All of the above are advantages O It can be used for treating infertility O They can be differentiated into many tissue types using appropriate growth factors * Previous Next
Answer with reason: When counseling parents about genetic transmission of an X-linked disorder, which concept does the nurse keep in mind? a. An X-linked disorder can be traced through the paternal lineage. b. A female can only pass an X-liked disorder to a son c. A male can pass an X-linked mutation to a son or a daughter d. A male with a mutation in an X-linked gene will manifest the disease. 5) The nurse explains to parents that if both of them are carriers of an autosomal recessive genetic mutation, the chance of each child NOT inheriting the disease (affected) is a. 25% c. 0% b. 75% d. 50% 0
Discuss two reasons why the therapeutic use ofembryonic stem cells can present a problem.
Please advise on the below for a punnet sqaure Brian is 15 months old. He has recently been diagnosed with X-linked ichthyosis. He is in the clinic with his family to receive the results of the genetic testing. The testing has been done to find out if Brian has an inherited or sporadic form of the disorder. Faisal and Nadia, Brian’s parents, are worried because they are expecting their second child, another boy, in about 3 months. Nadia’s medical notes reveal that she experienced significant post-natal depression after Brian’s birth. The clinician informs them that Nadia is a carrier of a causative mutation and asks them for a family history. Nadia explains that she has an older sister and that her mother miscarried a baby at about 16 weeks before going on to conceive Nadia. Nadia’s sister is married and has one healthy daughter aged 6. Nadia and her sister lost contact with their mother after she left their dad, but they are still in touch with their maternal grandmother, Lily, who…
You are a genetic counselor, and your patient has asked to be tested to determine if she carries a gene that predisposes her to early-onset cancer. If your patient has this gene, there is a 50/50 chance that all of her siblings inherited the gene as well; there is also a 50/50 chance that it will be passed on to their offspring. Your patient is concerned about confidentiality and does not want anyone in her family to know she is being tested, including her identical twin sister. Your patient is tested and found to carry a mutant allele that gives her an 85% lifetime risk of developing breast cancer and a 60% lifetime risk of developing ovarian cancer. At the result-disclosure session, she once again reiterates that she does not want anyone in her family to know her test results. a. Knowing that a familial mutation is occurring in this family, what would be your next course of action in this case? b. Is it your duty to contact members of this family despite the request of your patient? Where do your obligations lie: with your patient or with the patients family? Would it be inappropriate to try to persuade the patient to share her results with her family members?
Should he go ahead and enroll on the chance that he would receive the DNA vaccine and that it would be more effective than chemotherapy? Bruce and his parents moved to a semi-tropical region of the United States when he was about 3 years old. He loved to be outside year-round and swim, surf, snorkel, and play baseball. Bruce was fair-skinned, and in his childhood years, was sunburned quite often. In his teen years, he began using sunscreens, and although he never tanned very much, he did not have the painful sunburns of his younger years. After graduation from the local community college, Bruce wanted an outdoor job and was hired at a dive shop. He took people out to one of the local reefs to snorkel and scuba dive. He didnt give a second thought to sun exposure because he used sunscreen. His employer did not provide health insurance, so Bruce did not go for annual checkups, and tried to stay in good health. In his late 20s, Bruce was injured trying to keep a tourist from getting caught between the dive boat and the dock. He went to an internist, who treated his injury and told Bruce he was going to give him a complete physical exam. During the exam, the internist noticed a discolored patch of skin on Bruces back. She told him that she suspected Bruce had skin cancer and referred him to a dermatologist, who biopsied the patch. At a follow-up visit, Bruce was told that he had melanoma, a deadly form of skin cancer. Further testing revealed that the melanoma had spread to his liver and his lungs. The dermatologist explained that treatment options at this stage are limited. The drugs available for chemotherapy have only temporary effects, and surgery is not effective for melanoma at this stage. The dermatologist recommended that Bruce consider entering a clinical trial that was testing a DNA vaccine for melanoma treatment. These vaccines deliver DNA encoding a gene expressed by the cancer cells to the immune system. This primes the immune system to respond by producing large quantities of antibodies that destroy melanoma cells wherever they occur in the body. A clinical trial using one such DNA vaccine was being conducted at a nearby medical center, and Bruce decided to participate. At the study clinic, Bruce learned that he would be in a Phase Ill trial, comparing the DNA vaccine against the standard treatment, which is chemotherapy, and that he would be randomly assigned to receive either the DNA vaccine or the chemotherapy. He was disappointed to learn this. He thought he would be receiving the DNA vaccine.