B Which of the following is a Receptor Tyrosine Kinase? a. adenylyl cyclase b. B-adrenergic receptor c. enzyme receptor proteins d. a phospholipase C d. protein kinase C.
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- In relation to Cushing’s Syndrome, a method that some scientists have used to treat the disease is to use small molecules that bind to, but do not activate, MC2R. This type of molecule is considered an antagonist. How can an antagonist bind to the same receptor as ACTH but not activate it ? a. The antagonist binds covalently while ACTH binds non covalently b. The antagonist is only partially complimentary to the binding pocket of MC2R c. The antagonist binds to ACTH and blocks it from binding to the receptor properly d. The antagonist is the exact same structure as ACTH but since it is synthetic it doesn’t workThe function of monoamine oxidase is to a. convert norepinephrine into epinephrine b. speed up the digestion of cheese within the gut c. degrade catecholamines and serotonin into inactive forms d. convert dopamine into norepinephrine The detection of table salt (sodium chloride; NaCl) occurs by which receptor mechanism a. Closing of potassium channels b. Opening of calcium channels c. Diffusion of sodium ions into the cell through sodium channels d. Activation of a sodium-sensitive G protein-coupled receptorWhich of the following would inhibit the activity of TGF-Beta receptor? multiple answers A. Deletion of Extracellular domain B. Tyrosine Kinase Inhibitor C. Mutation that prevents homodimerization of Type II Receptor D. Mutation of phosphorylation site on Type I receptor E. Inhibition Type II receptor binding to Type I receptor
- xytocin stimulates contraction of smooth muscles in the breast and uterine wall. The key step in muscle contraction is release of calcium from internal cell stores. With which type of receptor does oxytocin interact to cause muscle contraction? A. Gαi-coupled receptor B. Tyrosine kinase coupled receptor C. Cytokine type 1 receptor D. Ser/Thr kinase receptor E. Gαq-coupled receptor8) Adrenergic receptors are the a. G-protein coupled receptor b. Ligand-gated ion channel c. Kinas-linked receptor d. Nuclear receptors e. Transport proteinsWhich second messenger pathway enzyme is used with alpha-2 adrenergic receptors? A. phosphodiesterase (PDE) B. adenylate cyclase C. ATP hydrolase
- Which of the following best describes the type of receptor a beta-antagonist drugs acts on a.Ligand-regulated transmembrane enzymes b.Ion channel c.G protein-coupled receptor d.Intracellular lipid-soluble signalingWhich of the following enzymes does NOT catalyzes the formation a second messenger? A. PI3K B. Protein kinase C C. Phospholipase C D. Guanylyl cyclase Which of the following statements is correct? A. Lipolysis is inhibited by epinephrine and glucagon B. Phosphorylation of triacylglycerol lipase inhibits its activity C. Activation of protein kinase A inhibits lipolysis D. Fatty acids are activated in mitochondria before undergoing b-oxidation E. Lipolysis is stimulated by cAMP F. None of the above10) Nicotinic receptors are a. G-protein coupled receptors b. Ligand-gated ion channels c. Kinas-linked receptors d. Nuclear receptors e. Transport proteins
- The drug Buckeyium binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume that glycine is already bound, and that magnesium is not blocking the NMDAR ion channel. If the channel does not open as a result of Buckeyium binding than Buckeyium would be considered a ____________. A. Indirect Antagonist B. Positive Allosteric Modulator C. Negative Allosteric Modulator D. None of the choice options are correct E. Non-Competitive AntagonistA ligand binds to the extracellular portion of a receptor. Another ligand binds to an identical half of the same receptor. When this happens, the two halves come together and the intracellular portion adds phosphates from ATP to tyrosine amino acids it the receptor structure. This passage describes what kind of receptor? Select one: a. A G-protein coupled receptor b. A receptor tyrosine kinase c. A receptor tyrosine phosphatase d. A ligand-gated kinase channelInteracellular receptors bind a. Hydrophilic molecules B. Cell membrane receptors c. Second messengers such as Camp d. Protein hormones e. Small signals that can diffuse through the cell membrane