Both the physical properties of the API and the excipients areessential to ensure that the formulation is physically stable andsuitable for administration to patients. Discuss the generalformulation considerations.2. The instability of emulsions may be either reversible orirreversible. Cracking indicates the extensive coalescence of theinternal phase, consequently, leads to the separation of theemulsion into two distinct layers.2a. How the cracking is occurring in the emulsions?2b. If an emulsion has cracked will it be recovered. If yes/nodiscuss the phenomena.3. Discuss the lyophilization and appraise its importance in thepharmaceutical industry with suitable examples.

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Answered: Both the physical properties of the API…

EBK A SMALL SCALE APPROACH TO ORGANIC L

4th Edition

ISBN:9781305446021

Author:Lampman

Publisher:Lampman

Chapter80: Crystallization: Purification Of Solids

Section: Chapter Questions

Problem 3P

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The solid is treated with hot water giving a solid and a solution. The solution is treated with K2CrO4 and no precipitate forms. What is your conclusion?
A. For each pair of compounds, fill in the appropriate information needed to distinguish them. Compound that will Positive Differentiating Chemical test sign/s of reaction Compound A Compound B react (А/B) COH Dissolution and (1) rapid bubbling (effervescence) (2) ОН OH NH2 H2N. HO. (3) (4) B Formation of O¯ Na O Na (5) white (6) precipitate Br (7) (8) (9)
The substance to be analyzed – is deep-pink colored, highly soluble in water salt. Reaction with NH; gives blue-colored precipitate, which can be dissolved in NH3 surplus accompanied by dirty-yellow colored solution formation. After precipitation of cation by "sodium carbonate drawing out" method, supernatant was independently treated by silver nitrate solution and barium chloride solution (in acid medium in both cases) – any precipitation hasn't been observed. Addition of antipyrin in acid medium changes color to red. What kind of substance is this? Co(NO3)2 CuCl2 Co(CH;COO), FeSO4
Give a clear handwritten answer with explanation...how you will prepare a series of 1 ppm quinine sulphate solutions that contain 0.010, 0.020, 0.030, 0.040, or 0.050 M sodium bromide.
Which among the following situations favors crystalline precipitate formation? Explain. a. Stirring slowly using reagents at room temp. b. Stirring slowly using reagents at high temp. c. Stirring vigorously using dilute solutions. d. none of the above
Briefly describe mechanism involve during formation of precipitate.
Absorbance 7. Compound 7 is a neutral, low-melting solid (mp - 22.24°C) Elemental Analysis: C-72.00%, H-6.67%, O-21.33% "C Spectral Data: 196.5ppm(s), 166.4ppm(s), 129.7ppm(s), 129.6ppm(d), 114.0ppm(d), 56.0ppm(q), 22.8ppm(q) Mass Spectrum Compound 7 Structure W Inlanalty Infrared Spectrom 4000 3000 2500 1 'H NMR 20 100 110 120 130 140 150 100 170 100 100 201 Wave Number, am 1600 1300 1300 1100 130 Wavelength, microns 700 CHEM 241L Exp#12 NMR Spectroscopy www................................. www. Ppm, 8 Rev. 052318JKO
Suggest possible crystallization solvents for the following compounds. Use IMF to predict the type of solvent each compound should be soluble in. Then, find the melting point and solubility of compounds in the handbook, and choose s recrystallization solvent
what is the solubility of phenazopyridine hydrochloride in the basic and acidic medium? with illustration, and chemical structure and its melting point .
2. A sample of material contains for its active components NaOH, NazCO3, NaHCO3, or compatible mixtures of these. Two samples, each weighing 1.000 g, are dissolved in H20. To one sample phenolphthalein is added and the solution is titrated cold with 1.038 N acid, of which 17.96 mL is required. The other sample is titrated cold, with methyl orange as indicator, and 21.17 mL of the same acid is required. What alkalis are present, and what is the percentage of each in the original sample?
A. For each pair of compounds, fill in the appropriate information needed to distinguish them. Positive Compound that will Compound A Compound B Differentiating Chemical test sign/s of react reaction (A/B) OH OH (1) Dissolution and rapid bubbling (effervescence) (2) OH NH₂ (3) (4) B (5) Formation of white precipitate (6) (7) (8) (10) (11) H₂N. OH OH OH H₂N H₂N H₂N OH S O==O O OH OH Na CH3 (9) (12)
Purification of benzoic acid 1. What is the purpose of washing the crystal in the filter paper with water? 2. How recrystallization affects the theoretical yield of sample? Explain.

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