calculate P1 for amino acid Tryptophan. Also please check if I draw the mechanism correctly and completely???

Understanding Health Insurance: A Guide to Billing and Reimbursement
14th Edition
ISBN:9781337679480
Author:GREEN
Publisher:GREEN
Chapter12: Commercial Insurance
Section: Chapter Questions
Problem 10R
icon
Related questions
Question
need help to calculate P1 for amino acid Tryptophan. Also please check if I draw the mechanism correctly and completely???
Thr, Threonine
соон
+
H3N-C-H
| PH, pka=2.63
H-C-OH
1
CH3
(+1)
-NH
(+1)
P1 =
Coo
+ 1
H₂N-C-H
H-C-OH
CH13
Tryptophan Trp
соон
1
+
H³N² - C-H = H₂ND_C
PH, pha=2.20
CH₂
P1 =
(0)
2.63 +0.43.
2
саб
1
H₂N-C-
PH=pka=10.43
(0)
н- с-он
1
CH3
= 6.53
Coo
Coo
1
C-M =H₂N-C-H
PHEpha 911 CH2
CH2
(-1)
-NH
(-1)
H
16
~
Transcribed Image Text:Thr, Threonine соон + H3N-C-H | PH, pka=2.63 H-C-OH 1 CH3 (+1) -NH (+1) P1 = Coo + 1 H₂N-C-H H-C-OH CH13 Tryptophan Trp соон 1 + H³N² - C-H = H₂ND_C PH, pha=2.20 CH₂ P1 = (0) 2.63 +0.43. 2 саб 1 H₂N-C- PH=pka=10.43 (0) н- с-он 1 CH3 = 6.53 Coo Coo 1 C-M =H₂N-C-H PHEpha 911 CH2 CH2 (-1) -NH (-1) H 16 ~
©2003 Brooks/Cole, a division of Thomson Learning, Inc.
TABLE 3.2 pK, Values of Common Amino Acids
Acid
a-COOH
a-NH
RH or RH
2.34
9.60
Gly
Ala
2.34
9.69
Val
2.32
9.62
Leu
2.36
9.68
Ile
2.36
9.68
Ser
2.21
9.15
Thr
2.63
10.43
Met
2.28
Phe
1.83
Trp
2.38
Asn
2.02
Gln
2.17
Pro
1.99
Asp
Glu
His
Cys
Tyr
- Lys
Arg
2.09
2.19
1.82
1.71
2.20
2.18
2.17
9.21
9.13
9.39
8.80
9.13
10.6
9.82
9.67
9.17
10.78
9.11
8.95
9.04
3.86*
4.25*
Table 3.2 PKa values of common amino acids
6.0*
8.33*
10.07
10.53
12.48
18
*For these amino acids the R group ionization occurs before the a-NH;
ionization.
RH
длягр
Transcribed Image Text:©2003 Brooks/Cole, a division of Thomson Learning, Inc. TABLE 3.2 pK, Values of Common Amino Acids Acid a-COOH a-NH RH or RH 2.34 9.60 Gly Ala 2.34 9.69 Val 2.32 9.62 Leu 2.36 9.68 Ile 2.36 9.68 Ser 2.21 9.15 Thr 2.63 10.43 Met 2.28 Phe 1.83 Trp 2.38 Asn 2.02 Gln 2.17 Pro 1.99 Asp Glu His Cys Tyr - Lys Arg 2.09 2.19 1.82 1.71 2.20 2.18 2.17 9.21 9.13 9.39 8.80 9.13 10.6 9.82 9.67 9.17 10.78 9.11 8.95 9.04 3.86* 4.25* Table 3.2 PKa values of common amino acids 6.0* 8.33* 10.07 10.53 12.48 18 *For these amino acids the R group ionization occurs before the a-NH; ionization. RH длягр
Expert Solution
steps

Step by step

Solved in 2 steps with 1 images

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Understanding Health Insurance: A Guide to Billin…
Understanding Health Insurance: A Guide to Billin…
Health & Nutrition
ISBN:
9781337679480
Author:
GREEN
Publisher:
Cengage
Comprehensive Medical Assisting: Administrative a…
Comprehensive Medical Assisting: Administrative a…
Nursing
ISBN:
9781305964792
Author:
Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy Correa
Publisher:
Cengage Learning