CLINICAL ASPECTS OF METABOLISM OF CARBOHYDRATES, AMINO ACIDS AND LIPIDS CLINICAL CONDITION/ PHYSIOLOGIC METABOLIC PROBLEM CONSEQUENCE/S SITUATION 1. CACHEXIA 2. PREGNANCY 3. LACTATION 4. DIABETES MELLITUS 5. KETOSIS
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- Diabetes mellitus is characterized by insufficiency of thepancreas to produce enough insulin to regulate the blood sugarlevel. In type I diabetes, the pancreas produces no insulin, andthe patient is totally dependent on insulin from an externalsource to be infused at a rate to maintain blood sugar levelsat normal levels. Hyperglycemia occurs when blood glucoselevel rises much higher than the norm (>8 mmol/L) for pro-longed periods of time; hypoglycemia occurs when the blood sugar level falls below values of 3 mmol/L. Both situations canbe deleterious to the individual’s health. The normal range ofblood sugar is between 3.8 and 5.6 mmol/L, the target rangefor a controller regulating blood sugar.A patient with type I diabetes needs your help to maintainher blood sugar within an acceptable range (3 mmol/L<glucose<8 mmol/L). She has just eaten a large meal (a disturbance) that you estimate will release glucose accord-ing toD(t)=0.5e−0.05t,wheretis in minutes andD(t)is inmmol/L –…Side-effects of non-steroidal anti- inflammatory drugs (NSAIDS) include all, except Peptic ulcer Reduced kidney function GIT bleeding O Seizures Ketoprofen: is a propionic acid derivative that inhibits both COX (non selectively) and * lipoxygenase True FalseLow insulin levels and low plasma amino acid levels Protein Catabolism Olher amino acids alpha-KG Glutamate Giutamne Gutamine Glutamate SO H Cystie)ine EGSH Cystfe)ineCyst(eline- Urea Skeletal Muscle Liver To the best of your abilities, explain the image above. Do not include other "unnecessary" things that you cannot see in the picture.
- Would a metabolic rational for a child who has a similar diet to other children but after infections or vigorous exercise has low blood glucose levels and increased lactic acid in the blood along with potential lethargy, shakiness and irritability be type 1 diabetes? Noting that an effective treatment for them is alanine supplementation in the diet.Discuss the 3 mechanisms of abnormal carbohydrates metabolism that result in the development of ketone bodies in the urine and give examples of the condition to each.Indicate whether the following metabolic processes primarily occur during the FED STATE or FASTED STATE. 1. Release of insulin 2. Release of glucagon 3. Glycolysis 4. Glycogenesis 5. Gluconeogenesis 6. Lipogenesis 7. Glycogenolysis 8. Lipolysis 9. Glucose release 10. Glucose uptake
- Figure 37.11 Pancreatic tumors may cause excess secretion of glucagon. Type I diabetes results from the failure of the pancreas to produce insulin. Which of the following statement about these two conditions is true? A pancreatic tumor and type I diabetes will have the opposite effects on blood sugar levels. A pancreatic tumor and type I diabetes will both cause hyperglycemia. A pancreatic tumor and type I diabetes will both cause hypoglycemia. Both pancreatic tumors and type I diabetes result in the inability of cells to take up glucose.Which of the following statements about insulin is true? Insulin acts as a transport protein, cany in g glucose across the cell membrane. Insulin facilitates the movement of inti acellular glucose transporters to the cell membrane. Insulin stimulates the breakdown of stored glycogen into glucose. Insulin stimulates the kidneys to reabsorb glucose into the bloodstream.Discusskey impairments that are characteristic in the altered glucose metabolism of people with Type 2 Diabetes. (note: you should describe effects in different key organs/tissues involved in glucose metabolism within your answer) As a result of these impairments, describethe expected differences in post-prandial metabolism of a given load of digestible carbohydrates in people with Type 2 Diabetes compared with healthy, non-diabetic individuals.
- Discuss how hormonal control of carbohydrates affects our ability to maintain healthy energy status. Discuss what specific outcomes could occur without this control.Saponification is a process by which triacylglycerols are hydrolyzed to produce glycerol and fatty acid salt by the action of a strong acid. True FalseEating non-fibrous carbohydrates can cause a cycle of glucose dependenceand hunger represented by a glucose crash. Explain this situation showing the levels of insulin and blood glucose under this situation