Consider the following from the Ampicillin for Injection, USP package insert: For Intramuscular Use: Label Claim 250mg 500mg 1g 2g Amount of Diluent (mL) Approx. Volume (ml) 0.9 1.7 3.4 6.8 1 2 4 8 a) What is the amount of diluent needed to reconstitute a 1 g vial? b) What is the powder volume for a 1 g vial of ampicillin? Approx. Concentration (mg/mL) 250 250 250 250 Later in the package insert you see: For Direct Intravenous Use: Add 5 mL Sterile Water for Injection or Bacteriostatic Water for Injection to the 250 and 500 mg vials and administer slowly over a 3 to 5-minute period. Ampicillin for Injection, 1 g or 2 g, may also be given by direct intravenous administration. Dissolve in 7.4 or 14.8 mL Sterile Water for Injection or Bacteriostatic Water for Injection, respectively, and administer slowly over at least 10 to 15 minutes. c) What is the amount of diluent needed to reconstitute a 1 g vial of ampicillin for direct IV injection d) What is the total amount of volume that will be removed from the vial and administered in a Direct Intravenous dose of 1g?
Consider the following from the Ampicillin for Injection, USP package insert: For Intramuscular Use: Label Claim 250mg 500mg 1g 2g Amount of Diluent (mL) Approx. Volume (ml) 0.9 1.7 3.4 6.8 1 2 4 8 a) What is the amount of diluent needed to reconstitute a 1 g vial? b) What is the powder volume for a 1 g vial of ampicillin? Approx. Concentration (mg/mL) 250 250 250 250 Later in the package insert you see: For Direct Intravenous Use: Add 5 mL Sterile Water for Injection or Bacteriostatic Water for Injection to the 250 and 500 mg vials and administer slowly over a 3 to 5-minute period. Ampicillin for Injection, 1 g or 2 g, may also be given by direct intravenous administration. Dissolve in 7.4 or 14.8 mL Sterile Water for Injection or Bacteriostatic Water for Injection, respectively, and administer slowly over at least 10 to 15 minutes. c) What is the amount of diluent needed to reconstitute a 1 g vial of ampicillin for direct IV injection d) What is the total amount of volume that will be removed from the vial and administered in a Direct Intravenous dose of 1g?
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 7.2P
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Transcribed Image Text:Consider the following from the Ampicillin for Injection, USP package insert:
For Intramuscular Use:
Label Claim
250mg
500mg
1g
2g
Amount of Diluent (mL) Approx. Volume (ml)
0.9
1.7
3.4
6.8
1
2
4
8
a) What is the amount of diluent needed to reconstitute a 1 g vial?
b) What is the powder volume for a 1 g vial of ampicillin?
Approx. Concentration
(mg/mL)
250
250
250
250
Later in the package insert you see:
For Direct Intravenous Use:
Add 5 mL Sterile Water for Injection or Bacteriostatic Water for Injection to the 250 and 500 mg
vials and administer slowly over a 3 to 5-minute period. Ampicillin for Injection, 1 g or 2 g, may also
be given by direct intravenous administration. Dissolve in 7.4 or 14.8 mL Sterile Water for Injection
or Bacteriostatic Water for Injection, respectively, and administer slowly over at least 10 to 15
minutes.
c) What is the amount of diluent needed to reconstitute a 1 g vial of ampicillin for direct IV injection
d) What is the total amount of volume that will be removed from the vial and administered in a
Direct Intravenous dose of 1g?
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