Cystic hibros Ife-threatering disease that causes thick, stcky mucus to buid up in areas of the body, inciuding the lungs. are studying CF TR associated with cystic fibrosis in fumans. In the majority of cystic fibrosis patients, the same mutation is seen in the same location on the CFTR gene. A partial DNA sequence, a partial MRNA transoript, and part of the normal polypetide that the makes up the CFTR protein that the CFTR gene codes for are shown in the dagram below. ONA STTA RNA STA Polypeptide A partial DNA sequence, a partiai MRNA transcript, and part of the CFTR polypeptide in a cystic fbrosis patient are shown in the diagram below. DNA 3 TTAO MRNA S Polypeptide Gy A Describe the change in the DNA sequence, the effect on the MRNA, and the effect on the polypeptide. B is this a "true" trameshift mutation? Why or why not? C. Would a single base insertion at the beginning of the gene have a larger or smaller effect on the resulting polypeptide than the CFTR mutation? Explain your answer.

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter9: Gene Expression And Gene Regulation
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Problem 10QP: The pre-mRNA transcript and protein made by several mutant genes were examined. The results are...
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Cystic fibrosis is a life-threatening disease that causes thick, sticky mucus to build up in areas of the body, including the lungs. Scientists are studying CFTR, the gene
associated with cystic fibrosis in humans. In the majority of cystic fibrosis patients, the same mutation is seen in the same location on the CFTR gene.
A partial DNA sequence, a partial MRNA transcript, and part of the normal polypetide that the makes up the CFTR protsin that the CFTR gene codes for are shown in
the diagram below.
DNA 3
MRNA S
Polypeptide
Gly
A partial DNA sequence, a partial MRNA transcript, and part of the CFTR polypeptide in a cystic fibrosis patient are shown in the diagram belaw.
DNA 3
MRNA 5
Polypeptide
A Describe the change in the DNA sequence, the effect on the MRNA, and the effect on the polypeptide.
Is this a "true" frameshift mutation? Why or why not?
B.
C. Would a single base insertion at the beginning of the gene have a larger or smaller effect on the resulting polypeptide than the CFTR mutation? Explain your
answer.
Transcribed Image Text:Cystic fibrosis is a life-threatening disease that causes thick, sticky mucus to build up in areas of the body, including the lungs. Scientists are studying CFTR, the gene associated with cystic fibrosis in humans. In the majority of cystic fibrosis patients, the same mutation is seen in the same location on the CFTR gene. A partial DNA sequence, a partial MRNA transcript, and part of the normal polypetide that the makes up the CFTR protsin that the CFTR gene codes for are shown in the diagram below. DNA 3 MRNA S Polypeptide Gly A partial DNA sequence, a partial MRNA transcript, and part of the CFTR polypeptide in a cystic fibrosis patient are shown in the diagram belaw. DNA 3 MRNA 5 Polypeptide A Describe the change in the DNA sequence, the effect on the MRNA, and the effect on the polypeptide. Is this a "true" frameshift mutation? Why or why not? B. C. Would a single base insertion at the beginning of the gene have a larger or smaller effect on the resulting polypeptide than the CFTR mutation? Explain your answer.
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