Draw the bond-line structure (using dash/wedge notation) for the compound below as it would exist at pH = 2 and pH = 7. Show your work. What is the percent ionization for each the amine and carboxylic acid functionality at each pH, respectively? correct structure correct structure at pH = 2.0 at pH = 7.0 It has been observed that in aqueous buffer (pH = 7) this compound is more likely to be in a chair conformation where both substituents are in axial positions than when in aqueous buffer (pH =2). Use chair structures to illustrate why the normally unfavorable 1,3-diaxial interactions may be energetically minimized at pH=7 vs. pH = 2.

Draw the bond-line structure (using dash/wedge notation) for the compound below as it would exist at pH = 2 and pH = 7. Show your work. What is the percent ionization for each the amine and carboxylic acid functionality at each pH, respectively? correct structure correct structure at pH = 2.0 at pH = 7.0 It has been observed that in aqueous buffer (pH = 7) this compound is more likely to be in a chair conformation where both substituents are in axial positions than when in aqueous buffer (pH =2). Use chair structures to illustrate why the normally unfavorable 1,3-diaxial interactions may be energetically minimized at pH=7 vs. pH = 2.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter4: Acids And Bases

Section: Chapter Questions

Problem 4.33P: Complete the equation for the reaction between each Lewis acid-base pair. In each equation, label...

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Given that Kb for ammonia is 1.8 * 10-5 and that for hydroxylamine is 1.1 * 10-8, which is the stronger base?
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