hospital, his physician told him that his infarction is the result of a long history of smoking. Explain the conclusion of the specialist. For that: a) explain the functions of lipoproteins in cholesterol transport using the schemes;
hospital, his physician told him that his infarction is the result of a long history of smoking. Explain the conclusion of the specialist. For that: a) explain the functions of lipoproteins in cholesterol transport using the schemes;
Chapter8: Forms Of Drugs And How They Act
Section: Chapter Questions
Problem 28RQ
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Transcribed Image Text:6. A 60-year-old man has been smoking since his 30s. After a heated argument with
his colleagues in office he experienced an acute pain across his chest, associated
with shortness of breath, a sense of light-headedness and sweating. He was
rushed to the hospital emergency department, where his clectrocardiogram
showed changes consistent with an acute infarction. Blood was sent to the
laboratory for biochemical tests, including the total cholesterol, LDL cholesterol
and HDL cholesterol. The blood lipid levels (in mg/dL) were: TAG – 290,
total cholesterol - 325, LDL cholesterol – 245, HDL cholesterol - 25. The
patient was treated intensively and got better. Before he was discharged from the
7.13. Hypercholesterolemia. Biochemical Aspects of Atherosclerosis. Cholesterol-Lowering Agents 393
hospital, his physician told him that his infarction is the result of a long history
of smoking. Explain the conclusion of the specialist. For that:
a) explain the functions of lipoproteins in cholesterol transport using the
schemes;
b) describe the structure of LDL receptor, regulation of its synthesis in the liver
and function in cholesterol metabolism;
c) name all possible causes of the hypercholesterolemia;
d) explain the mechanism of prolonged smoking on the hypercholesterolemia
and atherosclerosis development.
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