How do SSRI and MAOIs work? Which parts of the neural communication machinery do they target? Which neurotransmitters do they affect? What is the end result at the synapse?
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- How do SSRI and MAOIs work? Which parts of the neural communication machinery do they target? Which neurotransmitters do they affect? What is the end result at the synapse?
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- What role do the supporting cells play in neurotransmission ? Describe the role of at least two different types of Supporting cells. Are the supporting cells. as important as the neurons when it comes. to neural Communication ?What is a synapse, and what role does it play in nerve transmission?We talked about drug effects on neurons in sequence. The effect of alcohol is multi-faceted and the following question asks you to apply your knowledge. Imagine two neurons in sequence. The presynaptic neuron is GABAnergic and the postsynaptic neuron is dopaminergic. The effects of alcohol are not fully understood but it does seem to inhibit GABAnergic neurons. How would the release of dopamine from the postsynaptic neuron change in this case? Explain your answer, being sure to make each connection between concepts clear. If alcohol instead inhibited dopaminernergic neurons, in what way might the ion flow change in the dendrites of the postsynaptic neuron of this example?
- Selective serotonin reuptake inhibitors (SSRIs) are drugs that can alleviate symptoms of depression by blocking the reuptake of serotonin (5-HT) from the synaptic cleft, thereby increasing the amount of time that 5-HT remains active. Elevated levels of 5-HT within the synapse are associated with feelings of well-being; conversely, low levels of 5-HT are correlated with depressive symptoms. Recent studies have shown that SSRIs can also mediate their antidepressant effects by increasing brain levels of certain cytokines, including interferon gamma (IFNY). IFNY directly induces the expression of the protein p11 in neighboring neurons, which then interacts with 5-HTR4, a 5-HT transmembrane receptor. Figures 1 and 2 provide information about this interaction. 5-HTR4 protein (% of WT) expression CAMP levels (% change control) from 120T 100+ 80+ 60+ 40+ 20+ 0 MEM TOT Figure 1 5-HTR4 protein expression in plasma membrane-enriched fraction (MEM) of hippocampal lysate and in total hippocampal…What are the effects of alcohol on the synaptic transmission?How do the ANS and Endocrine System work together to maintain homeostasis in times of short-term and long term stress. How do the ANS and Endocrine System work together to maintain homeostasis in times of short-term and long term stress.
- Reserpine is a drug that can control high blood pressure by reducing the number of catecholamine neurotransmitters present in the synapse. Epinephrine, norepinephrine, and dopamine are examples of catecholamine neurotransmitters. One of the known side effects of reserpine is to cause the symptoms of Parkinson’s disease. Parkinson's disease is associated with dopamine. Parkinson's disease occurs when the nerve cells in the part of the brain that controls muscle movement are gradually destroyed and the neurons can no longer produce dopamine to coordinate muscle movements. Reserpine causes symptoms by a. inhibiting the release of dopamine from the presynaptic neuron b. blocking the dopamine receptor in the postsynaptic neuron c. breaking down the neurotransmitter acetylcholine in the synapse d. breaking down cholinesterase enzyme in the synapseWhich of the following could be used to describe Norepinephrine (NE)? Select all that apply. hormone neurotransmitter Secreted by most postganglionic parasympathetic fibers uses cholinergic receptors a beta blocker would decrease its activity Secreted by most postganglionic sympathetic fibers Next DroviousWhat is an impulse? What is synaptic transmission?