11. For many centuries, the Chinese have used extracts from a group erbs known as epedra totreat asthma. A compound named ephedrine that has been isolated from these herbs wasfound to be a potent dilator of air passages in the lungs. The structure for ephedrine is shownbelow.How many stereoisomers are possible for ephedrine? Clearly show how you arrived atyour determination.a.b. The stereoisomer shown below is the one that is pharmacologically active. What is theconfiguration of each of the asymmetric centers? Clearly label and state.HONHCH3CH3

How many stereoisomers are possible for ephedrine? Clearly show how you arrived at your determination. a. b. The stereoisomer shown below is the one that is pharmacologically active. What is the configuration of each of the asymmetric centers? Clearly label and state. OH NHCH3 CH3

How many stereoisomers are possible for ephedrine? Clearly show how you arrived at your determination. a. b. The stereoisomer shown below is the one that is pharmacologically active. What is the configuration of each of the asymmetric centers? Clearly label and state. OH NHCH3 CH3

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter3: Stereoisomerism And Chirality

Section: Chapter Questions

Problem 3.23P

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Question

11. For many centuries, the Chinese have used extracts from a group erbs known as epedra to
treat asthma. A compound named ephedrine that has been isolated from these herbs was
found to be a potent dilator of air passages in the lungs. The structure for ephedrine is shown
below.
How many stereoisomers are possible for ephedrine? Clearly show how you arrived at
your determination.
a.
b. The stereoisomer shown below is the one that is pharmacologically active. What is the
configuration of each of the asymmetric centers? Clearly label and state.
HO
NHCH3
CH3

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We can determine the possible stereoisomers by deciding the number of chiral carbon centres present in given pharmaceutical moiety and arrangements of substitutions provides detailed idea about configuration.

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For many centuries, the Chinese have used extracts from a group of herbs known as ephedra to treat asthma. A compound named ephedrine has been isolated from these herbs and found to be a potent dilator of air passages in the lungs. a. How many stereoisomers does ephedrine have? b. The stereoisomer shown here is the one that is pharmacologically active. What is the configuration of each of the asymmetric centers?