If the half-life for the decomposition of a drug is 4 hours, how long will it take for 225 mg of the drug to decompose by 30%. Assume first order kinetics and constant temperature.
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- Study problem 2 4. A coworker has just isolated a copper enzyme that catalyzes the conversion of oil sludge into soluble alcohols in the presence of O₂. There are two Cu atoms per protein, which consists of a single polypeptide chain. As the bioinorganic chemist on the project, you are given unlimited quantities of the protein for the purpose of determining the active site structure. You have at your disposal a number of physical techniques, including NMR and EPR spectrometers, a magnetic susceptometer, a Mössbauer instrument, an X-ray absorption beam line, a UV-VIS spectrophotometer, a Raman spectrometer, a magnetic circular dichroism instrument, but, alas, no X-ray diffractometer. You have time to complete measurements by only three techniques before you have to give a report to your colleague. Describe what measurements you would make, in what order you would make them to get the most out of time, what results you might expect, and how you would use this information to characterize…Question: What is edman degradation and why does no reaction occur when sungsanpin was subjected to edman degradation show using structures.29 (RBE) value of 20 for the a radiation, calculate the equivalent dose In miner in that year Problem 7: A patient with with uveal melanoma is treated at a cyclotron facility with energetic protons directed at a tumor in their eye, with a dose of 1.0 Gy administered over five sessions, What is the equivalent dose in Sv to the tumor? A 6 Type of Radiation O Sv X-rays 7-rays / rays > 32 kev rays <32 ke V Neutrons, thermal to slow (< 20 keV) Neutrons, fast (1 – 10 MeV) Protons (1 - 10 MeV) a-rays from radioactive decay to the lungs of the 17 10 (body), 32 (eyes) 10 (body), 32 (cycs) 20
- APPLICATION 1. Describe the role of HDLS and LDLS in cholesterol transport in the blood. What is the relationship of HDL and LDL levels to cardiovascular disease? 2. The main fatty acid component of the triacylglycerols in coconut oil is lauric acid, CH3(CH,)1,COOH. Explain why coconut oil is a liquid at room temperature despite the fact that it contains a large fraction of this saturated fatty acid. Can an individual survive on a completely fat-free diet? 3. Write your Answer here:Accelerated Stability Testing Data Determine the expiration date of a drug product with the initial drug concentration of 50 mg/tablet using the following accelerated stability testing data: log Temp Rate Constant (1/min) 1/T (oC) 70 1.73E-05 80 3.38E-05 90 6.45E-05 Reaction Kinetics - Accelerated Stability Testing log In k Rate Constant Temp (oC) Temp (к) (1/min) (1/K) k 70 1.73E-05 80 3.38E-05 90 6.45E-05Enzyme Kinetics question Enzyme used is 10uL of a 10 ng/uL solution to a reaction mix in a final volume of 2.0 mL. (Enzyme used is 20kDa monomeric enzyme if matters) Based off lineweaver burk where 300 uM of inhibitor is used noninhibited formula is y= 4x + 0.1 (x axis is 1/S 1/mM) (y axis is 1/Vo sec/mM) inhibited formula is y = 4x + 1 I found Km as 1 mM for inhibited Vmax as 1mM/sec for inhibited How would I find Kcat? How would I find Ki?
- Problem #2 a) How many ionizable groups does the tyrosine-alanine-isoleucine-glycine tetrapeptide core of ustiloxin B have? ( b) At neutral pH, what fraction of the total concentration of the tetrapeptide is expected to have the R group of the tyrosine residue in its deprotonated, anionic form (assuming that the pK, of the R group is the same as that of the free amino acid)? c) What is the pl of the tetrapeptide (assuming that the pK,'s of the N- and C-termini are also the same as the corresponding functional groups in a free amino acid)?Question based on SDS-PAGEI f you look at your loading buffer, what is the function of mercaptoethanol, SDS, glycerol and bromophenol blue?Situational Problems 1. With the prevalence in food of peeled cereals or bread made from high-grade flour, hypovitaminosis B1 may occur. Explain the role that vitamin B, plays in the body. For this: a) name the coenzyme which contains vitamin B, and enzymes, which require this coenzyme to function; b) write the process in which these enzymes are involved and explain how the process speed will change with a lack of B,; d) what discase develops in the absence of vitamin B,.
- ent Page Form Combine Files Protect Flatten File Ch. 7] PROBLEMS Share 390% Enzymes-2.pdf Help + < Problems 125 (142/434) Capture the ronction: Add Bookmark 7.1 The following results were obtained for an enzyme-catalysed reaction Substrate concentration (mmol 1¹¹): 5.0 Initial velocity (umol l´¹ min¯¹): 147 Calculate Km and Vmax 6.67 10.0 20.0 182 233 323 125 40.0 400Problems 14 and 15: some of the exponents are unclear. Here they are: 14. Calculate vi and the degree of inhibition caused by a competitive inhibitor under the following conditions:(a) [S]=2x10-3 Mand[I]=2x10-3 M(b) [S]=4x10-4 Mand[I]=2x10-3 M (c) [S]=7.5x10-3 Mand[I]=10-5 MAssume that Km = 2 x 10-3 M, Ki = 1.5 x 10-4 M and Vmax = 270 nmoles x liter-1 x min-1.The degree of inhibition is the percent of the uninhibited velocity reached in the presence of the inhibitor. 15. (a) What concentration of competitive inhibitor is required to yield 75% inhibition at a substrate concentration of 1.5 x 10-3 M if Km =2.9x10-4 M and Ki =2x10-5 M? (b)Towhatconcentration must the substrate be increased to reestablish the velocity at theoriginal uninhibited value?Materials - 2021FA-CHM-1O X Bb 4427577 d-fleet02-xythos.content.blackboardcdn.com/6086c260d7e8f/4427577?X-Blackboard-Expiration=1633143600000&X-Blackboard-Sig 6 / 9 100% Exercise 1: Standard Curve for Protein Measurements: A standard curve for protein concentration is often created using known concentrations of bovine serum albumin (protein). This process is called the Bradford Assay; it is a colorimetric assay. A special reagent turns blue when it binds to amino acids present in protein. The intensity of the color is best measured with a spectrophotometer (a device for comparing two light radiations, wavelength by wavelength). In the case of the Bradford Assay the greater the absorbance, the higher the protein concentration. A series of tests were performed on some samples and spectrophotometer: following measurements were obtained using a Protein Concentration (mg/ml) Absorbance (A) 0.26 0.098 0.56 0.213 0.383 0.84 1.12 0.473 1.40 0.527 TASKS: 1. Enter the data into Excel - the…
