"LD50" refers to the median "lethal dose," which is the concentration at which 50% of the population would die. Toxicologists also use dose-response curves to determine the median "toxic dose," or TD50. This is the dose required to cause a specific response or symptom (such as loss of hearing or headaches) for 50% the population. 100- 50 0 Linear dose-response curve, Low (a) Linear dose-response curve Dose LDSO Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings High 12. Approximately what is the threshold dose for the toxicant shown in the graph to the right? 13. What is the LD50 for the toxicant shown in the graph to the right? 100- 50 0 (a) sodat Low Linear dose-response curve. Dose (b) Dose-response curve with threshold Threshold 100 As shown in the graphs above, if the response begins at any dose and increases continuously as dosage increases, then it is referred to as a non-threshold response curve. However, if the response does not occur until after the dose exceeds a certain level, this is referred to as a threshold response curve. The threshold is the level at which the dose begins to cause a response. The NOEL (no observable effect level) is the highest dose or exposure level of a poison that produces no noticeable toxic effect on animals. Chemicals with a threshold dose-response tend to have higher acceptable levels (MCLs) in things like drinking water under the Clean Water Act. 11. What is the difference between an LD50 and a TD50? 50 Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Threshold Dose 5 putés 10 LD 50. 15 High LD50 1.9344 Doce Point 30 35 20 25 Dose (mg) 14. What is the difference between a non-threshold dose-response and a threshold dose-response"
"LD50" refers to the median "lethal dose," which is the concentration at which 50% of the population would die. Toxicologists also use dose-response curves to determine the median "toxic dose," or TD50. This is the dose required to cause a specific response or symptom (such as loss of hearing or headaches) for 50% the population. 100- 50 0 Linear dose-response curve, Low (a) Linear dose-response curve Dose LDSO Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings High 12. Approximately what is the threshold dose for the toxicant shown in the graph to the right? 13. What is the LD50 for the toxicant shown in the graph to the right? 100- 50 0 (a) sodat Low Linear dose-response curve. Dose (b) Dose-response curve with threshold Threshold 100 As shown in the graphs above, if the response begins at any dose and increases continuously as dosage increases, then it is referred to as a non-threshold response curve. However, if the response does not occur until after the dose exceeds a certain level, this is referred to as a threshold response curve. The threshold is the level at which the dose begins to cause a response. The NOEL (no observable effect level) is the highest dose or exposure level of a poison that produces no noticeable toxic effect on animals. Chemicals with a threshold dose-response tend to have higher acceptable levels (MCLs) in things like drinking water under the Clean Water Act. 11. What is the difference between an LD50 and a TD50? 50 Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Threshold Dose 5 putés 10 LD 50. 15 High LD50 1.9344 Doce Point 30 35 20 25 Dose (mg) 14. What is the difference between a non-threshold dose-response and a threshold dose-response"
Chapter15: Adult And Pediatric Dosages Based On Body Weight
Section: Chapter Questions
Problem 18SST
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Transcribed Image Text:"LD50" refers to the median "lethal dose," which is the concentration at which 50% of the population
would die. Toxicologists also use dose-response curves to determine the median "toxic dose," or TD50.
This is the dose required to cause a specific response or symptom (such as loss of hearing or headaches)
for 50% the population.
100-
50
0
Linear dose-response curve.
Low
(a) Linear dose-response curve
Dose
LD 50
Copyright 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
→ High
12. Approximately what is the threshold
dose for the toxicant shown in the
graph to the right?
Adanted from 1 Nauran
13. What is the LD50 for the toxicant
shown in the graph to the right?
100-
50-
0
Low
(weaver) asoodsad
Linear dose-response curve.
Dose
(b) Dose-response curve with threshold
As shown in the graphs above, if the response begins at any dose and increases continuously as dosage
increases, then it is referred to as a non-threshold response curve. However, if the response does not
occur until after the dose exceeds a certain level, this is referred to as a threshold response curve. The
threshold is the level at which the dose begins to cause a response. The NOEL (no observable effect level)
is the highest dose or exposure level of a poison that produces no noticeable toxic effect on animals.
Chemicals with a threshold dose-response tend to have higher acceptable levels (MCLs) in things like
drinking water under the Clean Water Act.
11. What is the difference between an LD50 and a TD50?
1001
Threshold
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
50
Threshold Dose
LD 50
OL
0
5- 10
KH
High
LD50-
4
Dee Paint
30
25
15. 20
Dose (mg)
14. What is the difference between a non-threshold dose-response and a threshold dose-response?
35
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