Loss of function mutations in the BRCA1 tumor suppressor gene dramatically increase the risk of breast, ovarian and prostate cancers. In the general U.S. population, about 1/400 people inherit a mutant BRCA1 allele, but in people of Ashkenazi Jewish descent, the frequency is much higher: about 1/40. Ashkenazis are a subset of all Jewish people, descended from a small group of individuals isolated for a period of time centuries ago by geographic and cultural factors. Based on this information, which of the following Hardy-Weinberg violations seems most likely to explain the higher frequency of BRCA1 alleles in modern day Ashkenazi Jewish people? O Genetic drift (founder or bottleneck effect) O Negative selection against wild type (functional) alleles of BRCA1 in Ashkenazi Jewish people O Inbreeding within the population of Ashkenazi Jewish people O Positive selection on the BRCA1 mutant allele in Ashkenazi Jewish people
Loss of function mutations in the BRCA1 tumor suppressor gene dramatically increase the risk of breast, ovarian and prostate cancers. In the general U.S. population, about 1/400 people inherit a mutant BRCA1 allele, but in people of Ashkenazi Jewish descent, the frequency is much higher: about 1/40. Ashkenazis are a subset of all Jewish people, descended from a small group of individuals isolated for a period of time centuries ago by geographic and cultural factors. Based on this information, which of the following Hardy-Weinberg violations seems most likely to explain the higher frequency of BRCA1 alleles in modern day Ashkenazi Jewish people? O Genetic drift (founder or bottleneck effect) O Negative selection against wild type (functional) alleles of BRCA1 in Ashkenazi Jewish people O Inbreeding within the population of Ashkenazi Jewish people O Positive selection on the BRCA1 mutant allele in Ashkenazi Jewish people
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter12: Genes And Cancer
Section: Chapter Questions
Problem 27QP: Studies have shown that there are significant differences in cancer rates among different ethnic...
Related questions
Question
17
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 3 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co…
Biology
ISBN:
9781305251052
Author:
Michael Cummings
Publisher:
Cengage Learning
Human Heredity: Principles and Issues (MindTap Co…
Biology
ISBN:
9781305251052
Author:
Michael Cummings
Publisher:
Cengage Learning