ne step in the gluconeogenesis pathway for the biosynthesis of glucose is the partial reduction of 3-phosphoglycerate to give glyceraldehyde 3-phosphate. The process occurs by phosphorylation with ATP to give 1.3-bisphosphoglycerate, eaction with a thiol group on the enzyme to give an enzyme-bound thioester, and reduction with NADH. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism.

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions
Section21.SE: Something Extra
Problem 41MP
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H-C -OH
CH₂OPO₂²-
3-phosphoglycerate
ATP ADP
Arrow-pushing Instructions
AC XT
H-C-OH
:O:
CH₂OPO3²-
=C²
H-C-OH
-O
OPO3² Enz-SH
3
CH₂OPO3²-
1,3-bisphosphoglycerate
ADP
PO
S-Enz
H-C-OH
CH₂OPO3²-
One step in the gluconeogenesis pathway for the biosynthesis of glucose is the partial reduction of 3-phosphoglycerate to give glyceraldehyde 3-phosphate. The process occurs by phosphorylation with ATP to give 1,3-bisphosphoglycerate,
reaction with a thiol group on the enzyme to give an enzyme-bound thioester, and reduction with NADH. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism.
[Enzyme-bound thioester]
NADH/H*
NAD*, Enz-SH
H
H-C-OH
CH₂OPO3²-
Glyceraldehyde 3-phosphate
:Ö:
H-C-OH
CH₂OPO3²-
ADP
29
Transcribed Image Text:H-C -OH CH₂OPO₂²- 3-phosphoglycerate ATP ADP Arrow-pushing Instructions AC XT H-C-OH :O: CH₂OPO3²- =C² H-C-OH -O OPO3² Enz-SH 3 CH₂OPO3²- 1,3-bisphosphoglycerate ADP PO S-Enz H-C-OH CH₂OPO3²- One step in the gluconeogenesis pathway for the biosynthesis of glucose is the partial reduction of 3-phosphoglycerate to give glyceraldehyde 3-phosphate. The process occurs by phosphorylation with ATP to give 1,3-bisphosphoglycerate, reaction with a thiol group on the enzyme to give an enzyme-bound thioester, and reduction with NADH. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. [Enzyme-bound thioester] NADH/H* NAD*, Enz-SH H H-C-OH CH₂OPO3²- Glyceraldehyde 3-phosphate :Ö: H-C-OH CH₂OPO3²- ADP 29
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