Norleucine (Nle) is a commonly used amino acid isostere for methionine (structure attached). Sketch a trace of an expected HPLC chromatogram of the tripeptide Ala-Gly-Nle after hydrolysis using a C18-reversed phase HPLC column.
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- H2N. 3. Norleucine (Nle) is a commonly used amino acid isostere for methionine (structure attached). Sketch a trace of an expected HPLC chromatogram of the tripeptide Ala-Gly-Nle after hydrolysis using a C18-reversed phase HPLC column. .COOHNorleucine (Nle) is a commonly used amino acid isostere for methionine (structure attached). sketch a trace of Ana expected HPLC chromatogrm of the tripeptide Ala- Gly-Nle after hydrolysis using a C18- reversed phase HPLC column H2N COOHNorleucine (Nle) is a commonly used amino acid isostere for methionine (structure attached). sketch a trace of Ana expected HPLC chromatogrm of the tripeptide Ala-Gly-Nle after hydrolysis using a C18-reversed phase HPLC column H2N СООН
- Q24) Consider the following data obtained from the size exclusion chromatography of polypropylene, which was made from propylene of molecular weight 42.08 g/mol. S.No. Number of Molecular Weight Molecules Range (g/mol) 5 8,000 - 16,000 16 16,000 - 24.000 3. 24 24,000 - 32,000 4 28 32,000 - 40,000 5 20 40,000 - 48,000 48,000 – 56,000 From the above data, determine a) Number average molecular weight (M). b) Weight average molecular weight ( Mw). c) Degree of polymerization (DP)A mixture of seven amino acids (glycine, glutamate, leucine, lysine, alanine, isoleucine, and aspartate) is separated by chromatography. Explain why only six spots show up when the chromatographic plate is coated with ninhydrin and heated.In a mixture of the five proteins listed below, which should elute second in size- exclusion (gel- filtration) chromatography? A) cytochrome c B) ribonuclease A C) immunoglobulin G D) RNA polymerase E) serum albumin M. = 13,000 Da M. = 13,700 Da M. = 145,000 Da M. = 450,000 Da M. = 68,500 Da
- +Protein Mr pl А 12,000 28,000 42,000 66,000 (a;) 103,000 (a2) 111,000 3 8.4 C 7.2 9 E 5 F 4.2 Predict how the proteins listed above will behave in a variety of separation and characterization procedures. For each chromatographic technique (you may assume that the protein remains “native," or non-denatured), list the order in which the proteins will elute (come of the end of the column): Size Exclusion Chromatography, pH 6.8 First Last Anion Exchange Chromatography, pH 9, using a salt gradient to elute First LastConsider the following setup of a capillary electrophoresis (CE) system: What are the two major factors contributing to the moving speed of molecules in a CE separation process? Does the analyte need to be charged for CE separation? Which type of analytes will reach the detector first, positively-charged or negatively-charged?The substances in the table below were chromatographed on a gel filtration column. Estimate the molecular weight of the unknown. Compound Blue Dextran 2000 Molecular weight 2 x 106 158 000 V. (mL) 17.7 Aldolase 35.6 Catalase 32.3 210 000 Ferritin 28.6 440 000 Thyroglobulin 25.1 669 000 Unknown 30.3
- Explain how we would run a paper chromatography on an amino acid sample (explain the procedure or method). In a paper chromatography of an amino acid, the solvent front traveled 12.0 cm while the amino acid traveled 6.0 cm. What is Rf value of the amino acid?A student analyzed a mixture of amino acids using thin layer chromatography where the stationary phase is a silica-coated plate. For the mobile phase, he used 50% ethyl acetate in hexane. The mixture contained three (3) amino acids whose structures are shown below. OH Hollo HO OH OH OH NH₂ NH₂ NH₂ Threonine Valine Glutamic acid a. Identify spots A, B, and C in the developed TLC plate below based on the structures of the amino acids above (ie. which spot is threonine, valine, glutamic acid?). Hint: determine how the structures of the given amino acids differ A. BO С. b. Threonine can be phosphorylated using an enzyme called protein kinase. Given the same conditions the student used in his analysis, will the phosphorylated threonine have a higher, smaller, or the same Rf value compared to threonine? Which of the following compounds would have the lowest Rf value in a TLC analysis? A. Hexane-2,3-diol B. Benzene C. Diethyl ether D. 1,3,5-cyclohexanetriolFerritin (molecular mass 450 000), transferrin (molecular mass 80 000), and ferric citrate were separated by size exclusion chromatography on Bio-Gel P-300. The column had a length of 37 cm and a 1.5-cm diameter. Eluate fractions of 0.65 mL were collected. The maximum of each peak came at the following fractions: ferritin, 22; transferrin, 32; and ferric citrate, 84. (That is, the ferritin peak came at an elution volume of 22 x 0.65 mL = 14.3 mL.) Assuming that ferritin is eluted at the interstitial volume and that ferric citrate is eluted at VM, find Kay for transferrin. Kay =
