|| || acetolactate synthase CH3 || + CH3CH2 CH3 + CO2 TPP НО CH2CH3 a-ketobutyrate a-aceto-a-hydroxybutyrate

Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter18: Carboxylic Acids
Section: Chapter Questions
Problem 18.53P
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Acetolactate synthase transfers the acyl group of pyruvate to alpha-ketobutyrate. This is the first step in the biosynthesis of the amino acid isoleucine. Propose a mechanism for this reaction.

||
||
acetolactate
synthase
CH3
||
+ CH3CH2
CH3
+ CO2
TPP
НО
CH2CH3
a-ketobutyrate
a-aceto-a-hydroxybutyrate
Transcribed Image Text:|| || acetolactate synthase CH3 || + CH3CH2 CH3 + CO2 TPP НО CH2CH3 a-ketobutyrate a-aceto-a-hydroxybutyrate
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