Reading Comprehension Question. This is a description of one type breast cancer. One in five invasive breast cancers is HER2-positive, making this one of the more common breast cancer subtypes in the United States. HER2-positive cancers are ER- and PR-negative and human epidermal growth factor receptor 2 (HER2)-positive. HER2-positive breast cancer cells carry too many copies of the HER2 gene, which makes HER2- protein receptors, found on breast cells. When they work normally, HER2 receptors control how a healthy breast cell grows, divides, and repairs itself. When they proliferate, the receptors tell
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- Please answer fast and all question other wise I will give downvote. QUESTION 1 Why is cancer a disease of old age ? A. Older DNA is more easily damaged B. There are fewer stem cells to repair tissue in older people C. DNA mutations accumulate with age QUESTION 2 The frequency of this molecular change in cancer cells makes it readily detectable by liquid biopsy. A. Point mutations B. Gene amplification C. DNA methylation D. PSA antigen QUESTION 3 Can surgery (with conventional chemotherapy if necessary) ever cure cancer? A. Yes, but typically only when cancer is detected at an early stage B. No, it simply prolongs life, usually by a few months C. Yes, even advanced cancer can frequently be cured by chemotherapy D. Only when it is combined with a targeted therapyQuestion 1. The picture below represents a karyotype from the lymphocytes of a child with developmental abnormalities. 11 2² 35 K K 13 19 14 20 15 21 22 16 10 b. What is unusual in this karyotype? 17 it X a. Is the child male or female? Explain your answer. 18 c. What is the name of the specific disease associated to this chromosomal abnormality? d. Briefly explain why genetic alterations like the one above may cause developmental abnormalities.Answer and explain your choice to the following multiple-choice questions about cancer-promoting mutations. The ABC gene undergoes multiple gene duplication events, producing multiple copies of this gene in the genome. This gene duplication event is associated with cancer. What would best describe the normal function of ABC gene? Inhibit cell growth and division Oncogene Inhibit apoptosis Metabolic enzyme EXPLAIN in 1-2 sentences: A mutation in the epidermal growth factor receptor (EGFR) causes it to send a positive signal along its intracellular signaling pathway, even without the EGF ligand bound to it. Knowing the function of a growth factor, how would you classify this mutation? an activating mutation in a tumor suppressor gene an activating mutation in a proto-oncogene a loss of function mutation in a tumor suppressor gene a loss of function mutation in a proto-oncogene EXPLAIN in 1-2 sentences: In an otherwise normal cell, what would be the immediate result of a…
- how do i expand this into 1000 words for a result section of a report The objective is to interpret the results of an RNA-Seq analysis to identify differentially expressed genes in breast cancer using figure 1. The data provided includes gene symbols, chromosome location, start and end points, strand, fold change, log2 fold change, p-value, and false discovery rate (FDR). The RNA-Seq analysis has identified several genes that are differentially expressed in breast cancer. These genes are located on various chromosomes and have varying levels of fold change, indicating the degree to which their expression levels differ between normal and cancerous cells. The gene with the highest fold change is EYA4, located on chromosome 6, with a fold change of 3604.4176. This indicates that the expression of this gene is over 3600 times higher in cancer cells compared to normal cells. The log2 fold change is 11.81555, which is a measure of the magnitude of the difference in gene expression. The…how do i expand this into 1000 words The objective is to interpret the results of an RNA-Seq analysis to identify differentially expressed genes in breast cancer using figure 1. The data provided includes gene symbols, chromosome location, start and end points, strand, fold change, log2 fold change, p-value, and false discovery rate (FDR). The RNA-Seq analysis has identified several genes that are differentially expressed in breast cancer. These genes are located on various chromosomes and have varying levels of fold change, indicating the degree to which their expression levels differ between normal and cancerous cells. The gene with the highest fold change is EYA4, located on chromosome 6, with a fold change of 3604.4176. This indicates that the expression of this gene is over 3600 times higher in cancer cells compared to normal cells. The log2 fold change is 11.81555, which is a measure of the magnitude of the difference in gene expression. The p-value for this gene is extremely low…Question 1. Describe and explain the epidemiological evidence supporting the view that cancer develops through a multi-step process involving increasingly severe stages.. Question 2. Describe and explain the genetic evidence supporting the view that cancer develops through a multi-step process involving increasingly severe stages.
- This is a blank question. Thank you in advance, Bloom Syndrome Bloom syndrome is a rare genetic disorder. It is characterized by short stature and a long narrow face with prominent nose and ears. There is also increased sensitivity to light. People who have the disorder often develop rashes on their face, forearms, and hands when they have been exposed to the sun. In addition, these people often suffer from chronic obstructive pulmonary disorder (COPD) and have a higher chance of developing cancer. The cause of this genetic disorder is a mutation in the BLM gene located on chromosome 15. The immediate effect of this mutation is that there is a defect in the functioning of the DNA helicase enzyme. What would be the effect of this mutation on DNA replication? What stage of the cell cycle would be most affected?macrophages Question 48 Please describe/name the structural variants describe in the picture: Courtesy of CRC Press/Taylor & Francis Group А. 1 ACGCTGCGGTTCGATAGT 2 ACGCTGCG-TTCGATAGT В. 1 ACGCTGCGGTT-CGATAGT ACGCTGCGGTTTCGATAGT C. 1 ACGCTGCGGTTCGATAGT ACGCTGC CA GATAGT D. 1 CACACACACACACACACACACACA 2 CACACACACACACACACACACA E. 1 100 100 | 100 100 2 100 100 100Question 9 Cancer can be described as v [ Select ] disease which results from a genetic [ Select ] an infectious Select ] cells
- Despite all that we know about cancer today, some types of cancers are still increasing in frequency. Lung cancer among nonsmoking women is one of these. What reason(s) might there be for this increasing problem?Why do signals indicating damage to cells result in increase in the expression of p21Cip1? I need new answerhow do i expand this into 1000 words The methodology employed to identify differentially expressed genes (DEGs) in breast cancer using RNA-Seq data involves several systematic steps integrating data retrieval, analysis, normalization, DEG identification, and functional annotation. Initially, raw RNA-Seq data is retrieved from the NCBI GEO database, specifically from dataset GSE216238 (Nakshatri, 2023), which encompasses samples from both breast cancer and normal tissue. Subsequently, the raw data was imported into Excel for initial analysis, leveraging its widespread availability and user-friendly interface. Gene expression data for breast cancer analysis was obtained from the Gene Expression Omnibus (GEO) database. The GEO homepage (https://www.ncbi.nlm.nih.gov/geo/) was accessed, and the "Query & Browse" tab was selected. Advanced Search: Under "Search GEO DataSets," an advanced search was conducted (https://www.ncbi.nlm.nih.gov/gds/advanced). Keywords "breast" and "cancer" were…