singlet oxygen, -An) Ros (Reactive oxygen species) such as supa oxide, thee & Hydhoxyl radices attack the double bonds of UFA and cause damage to membranes. celle can protect-themedves against its effecte by the mioxidant Scavenging angymes include glutathione, alcoltbate, and of tocophuol * Accokate is produced from D-glucokse & scavenger los produed by exposure to ozene * Non enzymatic antioxidants (free radical scavengers) • dietary & endogenous, compartmentalization. lopair of damaged components, metal sequestion converts ₂ radical to th₂0₂ and release og. citalare: Redues $1,9₂ to H₂O, prevents hydroxyl ladical tomation mostly in peroxisomes. J 2014 Vitamin E : Alpha-tocophuol Lipid solube, protects against lipid peroxidation in membranes * Nonentymatic terminator of free-radical chainreaction VHamin C: Aserbat * Dorsales e-to vitamin E to regenerate vitamin £ * Water soluble, circulates in blood and fluids to access membranes. * Redox co-enzyme for collagen syntheus. Glutathione puoxidase, glutathione reductase G₁st = glotathione (Glycine, cyclube, glotamile) • peroxidove = redreces #₂0L, oxidizes 2 SH groups- GISSG in mitochondria, cytocol, howe selenium * Reduitare = recycles the glotathione, reduces NADPH " Treating mice with 1.284g seleniom /kg body weight significantly restored the namal levels of these paramelos. Histological examinations of longs and liver confirmed the protective actions 의 selenium against the effects of exposure to water pipe smoke. Adminstration of low level of selenium, 1-784g selenium /kg body weight on sodium selerite, exerted protective effects against oxidativn 10-11-
singlet oxygen, -An) Ros (Reactive oxygen species) such as supa oxide, thee & Hydhoxyl radices attack the double bonds of UFA and cause damage to membranes. celle can protect-themedves against its effecte by the mioxidant Scavenging angymes include glutathione, alcoltbate, and of tocophuol * Accokate is produced from D-glucokse & scavenger los produed by exposure to ozene * Non enzymatic antioxidants (free radical scavengers) • dietary & endogenous, compartmentalization. lopair of damaged components, metal sequestion converts ₂ radical to th₂0₂ and release og. citalare: Redues $1,9₂ to H₂O, prevents hydroxyl ladical tomation mostly in peroxisomes. J 2014 Vitamin E : Alpha-tocophuol Lipid solube, protects against lipid peroxidation in membranes * Nonentymatic terminator of free-radical chainreaction VHamin C: Aserbat * Dorsales e-to vitamin E to regenerate vitamin £ * Water soluble, circulates in blood and fluids to access membranes. * Redox co-enzyme for collagen syntheus. Glutathione puoxidase, glutathione reductase G₁st = glotathione (Glycine, cyclube, glotamile) • peroxidove = redreces #₂0L, oxidizes 2 SH groups- GISSG in mitochondria, cytocol, howe selenium * Reduitare = recycles the glotathione, reduces NADPH " Treating mice with 1.284g seleniom /kg body weight significantly restored the namal levels of these paramelos. Histological examinations of longs and liver confirmed the protective actions 의 selenium against the effects of exposure to water pipe smoke. Adminstration of low level of selenium, 1-784g selenium /kg body weight on sodium selerite, exerted protective effects against oxidativn 10-11-
Chapter22: Carbonyl Alpha-substitution Reactions
Section22.SE: Something Extra
Problem 63AP: As far back as the 16th century, South American Incas chewed the leaves of the coca bush,...
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TRANSCRIBE THE FOLLOWING TEXT IN DIGITAL FORMAT
Transcribed Image Text:Ans: 1) Ros
singlet oxygen,
(Rearlive oxygen species) Buch as
Supa oxide, thee & Hydroxy! radices attack the double
bonds of UFA and cause damage to membranes.
celle can protect-themedves against its effecti
by the Anlexidant scavenging anymDY
glutathione, ascoitbate, and of tocophuol
include
* Accokate is prodund from D-glucokse & scavenger
los prodund by exposure to ozenie
* Non entymatic antioxidants (free radical scavengers)
- dietary & endogenous, compartmentalization.
Repair of damaged components, metal sequestration
converts ₂ radical to #1₂02 and releaus Oy.
catalane: Redull H/9, to H₂0, prevents hydroxy/
ladical tomation mostly in puoxisomes.
a
a
204 Vitamin E: Alpha-tocophuol
* Lipid solube, protects against lipid peroxidation in
membranes.
* Nonentymatic terminator of free radical chain reaction
Hamin C: Ascobale
* Dorsales e-to vitamin E to regeneite Vitamin &
* Water soluble, cinculates in blood and fluids to
access membranes.
* Redox co-enzyme for collagen syntheirs.
GSH =
3.) Glutathione peroxidase, glutathione reductasa
glutathione (Glycine, cyclube, glotamile)
* peroxidane = reduces #₂0L, oxidizes 2 SH groups-
GSSG in mitochondria, cytosol, howe selenium
* Reduitare = recycles the glotathione, reduces
NADPH
4) Treating mice with 1.284g seleniom /kg body
weight significantly restored the namal levels
of these parameters. Histological examinations
of longs and liver confirmed the protective
actions 의
selenium against the effects of
exposure to water pipe smoke.
* Adminstration of low level of selenium, 1-784g
selenium /kg body weight aus sodium selenike,
exerted protective effects against oxidative
stress.
10-11-1
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