Temperature effect on the degradation of a multisulfa preparation was evaluated at 60 and 70°C. If the first-order reaction rate constants responsible for the degradation at these two temperatures were 8.2 x 10-4 and 1.96 x 10-3 hr-1,   Calculate the activation energy, Ea, for this drug in this temperature range (in kcal/mole). (The gas constant; R = 1.987 cal/deg mole):

Chemistry: The Molecular Science
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Author:John W. Moore, Conrad L. Stanitski
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Chapter11: Chemical Kinetics: Rates Of Reactions
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Temperature effect on the degradation of a multisulfa preparation was evaluated at 60 and 70°C. If the first-order reaction rate constants responsible for the degradation at these two temperatures were 8.2 x 10-4 and 1.96 x 10-3 hr-1,

 

Calculate the activation energy, Ea, for this drug in this temperature range (in kcal/mole).

(The gas constant; R = 1.987 cal/deg mole):

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