The Cystic Fibrosis receptor (CFTR) is a transmembrane protein that functions as an ion channel allowing facilitated diffusion of Cl- ions across the plasma membrane. The delta 508 mutation in the amino acid sequence causes a phenylalanine (F) to be deleted from the sequence at position 508. This mutation causes it to fold incorrectly into its tertiary structure after translation which stops its progression through the endomembrane system. In what compartment in the cell do you think this folding defect most likely occurs? Golgi rough ER smooth ER nucleus
The Cystic Fibrosis receptor (CFTR) is a transmembrane protein that functions as an ion channel allowing facilitated diffusion of Cl- ions across the plasma membrane. The delta 508 mutation in the amino acid sequence causes a phenylalanine (F) to be deleted from the sequence at position 508. This mutation causes it to fold incorrectly into its tertiary structure after translation which stops its progression through the endomembrane system. In what compartment in the cell do you think this folding defect most likely occurs? Golgi rough ER smooth ER nucleus
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:The Cystic Fibrosis receptor (CFTR) is a transmembrane protein that functions
as an ion channel allowing facilitated diffusion of Cl- ions across the plasma
membrane. The delta 508 mutation in the amino acid sequence causes a
phenylalanine (F) to be deleted from the sequence at position 508. This
mutation causes it to fold incorrectly into its tertiary structure after translation
which stops its progression through the endomembrane system. In what
compartment in the cell do you think this folding defect most likely occurs?
Golgi
rough ER
smooth ER
nucleus
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