The success of renal transplantation depends on three human histocompatibility genes, HLA-A, HLA-B and HLA-C, which must match between the donor and the receiver. A single mismatch may cause the kidney rejection. Each gene has multiple co-dominant alleles. These three genes are located very close to each other on chromosome 6, so that the recombination rate is very low (below 1%). The father has the following genotype: A1, A2, B24, B10, Cw4 and Cw7 and the mother is A1, A1, B11, B7, Cw5 and Cw8. Their first boy is A1, A1, B24, B11, Cw7 and Cw8. What is the probability that the second child is compatible with his/her brother?
The success of renal transplantation depends on three human histocompatibility genes, HLA-A, HLA-B and HLA-C, which must match between the donor and the receiver. A single mismatch may cause the kidney rejection. Each gene has multiple co-dominant alleles. These three genes are located very close to each other on chromosome 6, so that the recombination rate is very low (below 1%). The father has the following genotype: A1, A2, B24, B10, Cw4 and Cw7 and the mother is A1, A1, B11, B7, Cw5 and Cw8. Their first boy is A1, A1, B24, B11, Cw7 and Cw8. What is the probability that the second child is compatible with his/her brother?
Chapter26: Nutrient–gene Interactions In Health And Disease
Section: Chapter Questions
Problem 11RQ
Related questions
Question
100%
Question:-
The success of renal transplantation depends on three human histocompatibility genes, HLA-A, HLA-B and HLA-C, which must match between the donor and the receiver. A single mismatch may cause the kidney rejection. Each gene has multiple co-dominant alleles. These three genes are located very close to each other on chromosome 6, so that the recombination rate is very low (below 1%).
The father has the following genotype: A1, A2, B24, B10, Cw4 and Cw7 and the mother is A1, A1, B11, B7, Cw5 and Cw8. Their first boy is A1, A1, B24, B11, Cw7 and Cw8. What is the probability that the second child is compatible with his/her brother?
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you