True or False 1. There can be a quantitative determination of the degree of supercoiling in a DNA sample. 2. Topoisomerases can cut phosphodiester bonds and the DNA ligases will have to seal the nicks whenever there is a need to relieve the supercoiling. 3. Histone proteins are able to associate with DNA segments because of the anionic nature of the amino acids arg and lys.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter14: Biotechnology And Society

Section: Chapter Questions

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Concept explainers

Genome annotation

The technique of linking biological information to genome sequences is termed genome annotation. Gene annotation is the method of identifying gene locations and coding sections. It helps us understand what these genes are doing in the body through establishing structural characteristics and linking them to the actions of various proteins.

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True or False 1. There can be a quantitative determination of the degree of supercoiling in a DNA sample. 2. Topoisomerases can cut phosphodiester bonds and the DNA ligases will have to seal the nicks whenever there is a need to relieve the supercoiling. 3. Histone proteins are able to associate with DNA segments because of the anionic nature of the amino acids arg and lys. 4. The supercoiled DNA can either be positively or negatively supercoiled. 5. The Sanger method of DNA sequencing follows the principle of complementarity just like in the replication process.

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