What are the properties of the wild type amino acid, Tyrosine at position 368? Hint: the amino acids are numbered in order starting at the N-terminus.
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Q: A glycine residue is in position 210 of the tryptophan synthetase enzyme of wild-type E. coli. If…
A: Single base substitutions in which change in only one base pair occurs.
Q: Since among the 64 codons of mRNA 61 codify amino acids that form polypeptide chains what are the…
A: The function of the other codons is stop codon i-e to stop the translation.
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Q: Lactose permease, a protein of E. coli, is composed of a single polypeptide that is 417 amino acids…
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Q: . Give two reasons to explain why a proline residue in the middle of an ahelix is predicted to be…
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Q: What are the amino acids carried by tRNAs if their anticodons are either 5'-CAU-3' and 3'-GUC-5'?
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Q: Why is the pKa of the arginine side chain greater than the pKa of the lysine side chain?
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What are the properties of the wild type amino acid, Tyrosine at position 368?
Hint: the amino acids are numbered in order starting at the N-terminus.
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- Lactose permease, a protein of E. coli, is composed of a single polypeptide that is 417 amino acids in length. By convention, the amino acids within a polypeptide are numbered from the aminoterminus to the carboxyl-terminus. Are the following questions about lactose permease true or false? A. Because the 64th amino acid is glycine and the 68th amino acid is aspartic acid, the codon for glycine, 64, is closer to the 3′ end of the mRNA than the codon for aspartic acid, 68. B. The mRNA that encodes lactose permease must be greater than 1241 nucleotides in length.What is the length in AA’s of the LilP protein? Assume fMet is NOT CLEAVED. Write out the sequence of the polypeptide in AA: use the three letter notation, e.g. Met-Ser-Pro-The bacterially produced antibiotic gramicidin A forms channels in cell membranes that allow the free diff usion of Na+ and K+ ions, thereby killing the cell. This peptide consists of a sequence of Dand L-amino acids. The sequence of a segment of fi ve amino acids in gramicidin A is R-Gly-L-Ala-D-Leu-L-Ala-D-Val-R′. Complete the Fischer projection below by adding the correct group to each vertical bond.
- Consider the peptide Asp-Lys-Phe-Glu-Asn-Tyr-Gln-Val-Cys. In a single beaker, you treat this peptide with 2 proteases. One protease cleaves at the N-terminus of aromatic R groups and the other cleaves at the C-terminus of polar, non-ionizable R groups. Following the enzymatic digestion, you want to separate your peptide fragments so that you can identify them. You choose to separate the fragments using an anion exchange column. Beginning at pH=6 you apply your peptide fragments to the column and you gradually decrease the pH of the column stopping the separation when the pH of the column equals 4. Omitting chemical structures, write the amino acid sequence of the peptide fragments that are produced from this digest. Write the order that these fragments will elute from the column (if at all). (Relevant pKa values are: 2.1, 3.8, 4.3, 8.3, 9.6, 10.1, and 10.5)Remembering that the amino acid side chains projecting from each polypeptide backbone in a β sheet point alternately above and below the plane of the sheet, consider the following protein sequence: Leu-Lys-Val-Asp-Ile-Ser-Leu-Arg- Leu-Lys-Ile-Arg-Phe-Glu. Do you find anything remarkable about the arrangement of the amino acids in this sequence when incorporated into a β sheet? Can you make any predictions as to how the β sheet might be arranged in a protein?Isoleucine is encoded by three codons (5')AUU, (5')AUC, and (5')AUA. These three codons are recognized by a single tRNAle molecule. Based on the wobble hypothesis, the anticodon sequence in tRNAle must be O (5')AUI O (5')UAG O (5')IAU O (5')UAI O (5')GAU
- This is Fos-Jun dimer (1FOS). Is the leucine zipper at the C-terminus or at the N-terminus of the helices? Are the helices parallel or antiparallel?There are different tRNAs for each amino acid. What is one major way to differentiate among the tRNAs for each amino acid?What are the amino acids carried by tRNAs if their anticodons are either 5'-CAU-3' and 3'-GUC-5'?
- Determine the codon sequence for the peptide sequence glycylserylcysteinylarginylalanine. How many possibilities are there?Lactose permease, a protein of E. coli, is composed of a singlepolypeptide that is 417 amino acids in length. By convention, theamino acids within a polypeptide are numbered from the aminoterminalend to the carboxyl-terminal end. Are the following questionsabout lactose permease true or false?A. Because the sixty-fourth amino acid is glycine and the sixty- eighth amino acid is aspartic acid, the codon for glycine,64, is closer to the 3′ end of the mRNA than the codon for aspartic acid, 68.B. The mRNA that encodes lactose permease must be greater than1241 nucleotides in length.Draw and label the following RNA tetranucleotide: 5’phosphoryl-A-2’O-methyl-C-U-G-3’-phosphate