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- With references added,give a detailed mechanism of action for the drug Entresto.Please Write the Drug Discovery Process of Diltiazem? Please write at your own words.Why do the penicillin and cephalosporin groups of drugs have mildertoxicity than other antibiotics? What are their primary side effects?
- For each of the following antibiotics, give the spectrum, primary effect and briefly explain the mechanism of action: 1) Penicillins 2) Po1yrrryxin B 3) Vancomycin 4) TetracyclinsDescribe: a.) the mechanism of action of PF-07321332, the active compound found in the antiviral drug Paxlovid; b.) the viral target that it inhibits; and c.) the product formed. Use schemes where appropriate to support your answer. H H" H NH NH PF-07321332 FWhat are the primary medical practices that result in antimicrobial drug resistance? How can these be overcome?
- Why is it better for a drug to be microbicidal than microbistatic?Polymer nanoparticles, Microparticles and hydrogels have been developed for slow and sustained drug release for slow and sustained drug release application; mark all that apply below: 1)Drug release from hydrogels can be via (a) drug diffusion, (b) degradation of the polymeric matrix and (c) swelling 2) PLGA degrades to lactic acid and glycolic acid, which are not biocompatible 3) Drug release can be triggered through internal and external stimuli - I.e. by use of pH labile chemistries or external triggers 4) Burst release describes the initial faster release rates often observed in drug delivery system, which is then followed by sustained release 5) while burst release is observed with polymer nanoparticles, it is not observed from hydrogelsHow we can improve these parameters(isomerism, isosteric replacement) for the development of H1-Antihistamine drugs?
- Name and describe three mechanisms of acquired antimicrobial resistance tools that microbes may use to thwart drug action.Identify the classification of drug metabolism and specific type of reaction involved in each drugsample. Identify the enzyme involved in each reaction.Below, you can see a picture of an antimicrobial drug. Regarding semi-synthetic antimicrobial drug development to try to avoid development of antibiotic resistance, use 1 sentence to address what is the significance/value of the presence of the various R-groups (e.g. R4, R5, R6, etc.)?