Answered: When the enzymatic decarboxylation of…

When the enzymatic decarboxylation of acetoacetate is carried out in H218O, all the acetone that is formed contains 18O. What does this tell you about the mechanism of the reaction?

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter19: Enolate Anions And Enamines

Section: Chapter Questions

Problem 19.48P

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Question

When the enzymatic decarboxylation of acetoacetate is carried out in H₂
¹⁸O, all the acetone that is formed contains ¹⁸O. What does this tell you about the mechanism of the reaction?

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